日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The impact of aging on primate hematopoiesis as interrogated by clonal tracking

通过克隆追踪研究衰老对灵长类动物造血的影响

Yu, Kyung-Rok; Espinoza, Diego A; Wu, Chuanfeng; Truitt, Lauren; Shin, Tae-Hoon; Chen, Shirley; Fan, Xing; Yabe, Idalia M; Panch, Sandhya; Hong, So Gun; Koelle, Samson; Lu, Rong; Bonifacino, Aylin; Krouse, Allen; Metzger, Mark; Donahue, Robert E; Dunbar, Cynthia E

Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model

在恒河猴干细胞基因治疗模型中,必须采用高剂量全身照射才能实现有效的细胞植入和耐受性。

Uchida, Naoya; Weitzel, R Patrick; Shvygin, Anna; Skala, Luke P; Raines, Lydia; Bonifacino, Aylin C; Krouse, Allen E; Metzger, Mark E; Donahue, Robert E; Tisdale, John F

Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study

恒河猴干细胞移植后淋巴组织恢复的不一致性:一项体内成像研究

Donahue, Robert E; Srinivasula, Sharat; Uchida, Naoya; Kim, Insook; St Claire, Alexis; Duralde, Gorka; DeGrange, Paula; St Claire, Marisa; Reba, Richard C; Bonifacino, Aylin C; Krouse, Allen E; Metzger, Mark E; Paik, Chang H; Lane, H Clifford; Tisdale, John F; Di Mascio, Michele

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study

一项长达十年的克隆追踪研究揭示了非人灵长类动物造血干细胞再生的动态过程

Kim, Sanggu; Kim, Namshin; Presson, Angela P; Metzger, Mark E; Bonifacino, Aylin C; Sehl, Mary; Chow, Samson A; Crooks, Gay M; Dunbar, Cynthia E; An, Dong Sung; Donahue, Robert E; Chen, Irvin S Y

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number

整合特异性体外评估慢病毒转导的恒河猴CD34(+)细胞与体内载体拷贝数相关

Uchida, Naoya; Evans, Molly E; Hsieh, Matthew M; Bonifacino, Aylin C; Krouse, Allen E; Metzger, Mark E; Sellers, Stephanie E; Dunbar, Cynthia E; Donahue, Robert E; Tisdale, John F

High-efficiency transduction of rhesus hematopoietic repopulating cells by a modified HIV1-based lentiviral vector

利用改良的基于HIV1的慢病毒载体高效转导恒河猴造血干细胞

Uchida, Naoya; Hargrove, Phillip W; Lap, Coen J; Evans, Molly E; Phang, Oswald; Bonifacino, Aylin C; Krouse, Allen E; Metzger, Mark E; Nguyen, Anh-Dao; Hsieh, Matthew M; Wolfsberg, Tyra G; Donahue, Robert E; Persons, Derek A; Tisdale, John F

Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B

在非人灵长类动物AAV基因转移治疗B型血友病的模型中,通过药物调节体液免疫。

Mingozzi, Federico; Chen, Yifeng; Murphy, Samuel L; Edmonson, Shyrie C; Tai, Alex; Price, Sandra D; Metzger, Mark E; Zhou, Shangzhen; Wright, J Fraser; Donahue, Robert E; Dunbar, Cynthia E; High, Katherine A

Accelerated lymphocyte reconstitution and long-term recovery after transplantation of lentiviral-transduced rhesus CD34+ cells mobilized by G-CSF and plerixafor

粒细胞集落刺激因子 (G-CSF) 和普乐沙福 (plerixafor) 动员慢病毒转导的恒河猴 CD34+ 细胞移植后,淋巴细胞重建加速,长期恢复良好。

Uchida, Naoya; Bonifacino, Aylin; Krouse, Allen E; Metzger, Mark E; Csako, Gyorgy; Lee-Stroka, Agnes; Fasano, Ross M; Leitman, Susan F; Mattapallil, Joseph J; Hsieh, Matthew M; Tisdale, John F; Donahue, Robert E

Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures

Plerixafor (AMD3100) 和粒细胞集落刺激因子 (G-CSF) 根据整体基因和微RNA表达特征动员不同的CD34+细胞群

Donahue, Robert E; Jin, Ping; Bonifacino, Aylin C; Metzger, Mark E; Ren, Jiaqiang; Wang, Ena; Stroncek, David F

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.

通过慢病毒转导药物耐药基因,在恒河猴体内选择造血祖细胞并增强替莫唑胺剂量

Larochelle Andre, Choi Uimook, Shou Yan, Naumann Nora, Loktionova Natalia A, Clevenger Joshua R, Krouse Allen, Metzger Mark, Donahue Robert E, Kang Elizabeth, Stewart Clinton, Persons Derek, Malech Harry L, Dunbar Cynthia E, Sorrentino Brian P