Inhibition of adenylyl cyclase 1 (AC1) and exchange protein directly activated by cAMP (EPAC) restores ATP-sensitive potassium (K(ATP)) channel activity after chronic opioid exposure.

抑制腺苷酸环化酶 1 (AC1) 和 cAMP 直接激活的交换蛋白 (EPAC) 可恢复慢性阿片类药物暴露后 ATP 敏感钾 (K(ATP)) 通道的活性