日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

基于结构的高效WD重复结构域5抑制剂的发现，在临床前动物模型中证实了其疗效和安全性。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2211297120
Teuscher, Kevin B; Chowdhury, Somenath; Meyers, Kenneth M; Tian, Jianhua; Sai, Jiqing; Van Meveren, Mayme; South, Taylor M; Sensintaffar, John L; Rietz, Tyson A; Goswami, Soumita; Wang, Jing; Grieb, Brian C; Lorey, Shelly L; Howard, Gregory C; Liu, Qi; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W
发表日期：2023
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Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors

基于结构的高效、口服生物利用度高的苯并唑酮类WD重复结构域5抑制剂的发现

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c01529
Teuscher, Kevin B; Mills, Jonathan J; Tian, Jianhua; Han, Changho; Meyers, Kenneth M; Sai, Jiqing; South, Taylor M; Crow, Mackenzie M; Van Meveren, Mayme; Sensintaffar, John L; Zhao, Bin; Amporndanai, Kangsa; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W
发表日期：2023
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Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.

发现和基于结构的强效选择性 WD 重复结构域 5 (WDR5) 抑制剂，该抑制剂含有二氢异喹啉酮双环核心

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.9b01608
Tian Jianhua, Teuscher Kevin B, Aho Erin R, Alvarado Joseph R, Mills Jonathan J, Meyers Kenneth M, Gogliotti Rocco D, Han Changho, Macdonald Jonathan D, Sai Jiqing, Shaw J Grace, Sensintaffar John L, Zhao Bin, Rietz Tyson A, Thomas Lance R, Payne William G, Moore William J, Stott Gordon M, Kondo Jumpei, Inoue Masahiro, Coffey Robert J, Tansey William P, Stauffer Shaun R, Lee Taekyu, Fesik Stephen W
心血管
发表日期：2020
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