日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis.

抗焦谷氨酸-3 Aβ 免疫疗法可激活小胶质细胞，并抑制 Aβ 淀粉样变性转基因小鼠模型中的淀粉样蛋白积累

期刊:Acta Neuropathologica
影响因子:9.3
doi:10.1007/s00401-025-02892-5
Liao Fan, Calvo-Rodriguez Maria, Chhaya Meha, Sefrin Julian P, Charych Erik I, Mezler Mario, Clausznitzer Diana, McGlame Emily J, Zhao Karen, Rodgers Allison, Cao Yang, Secker Philipp F, Fernandez Garcia-Agudo Laura, Huang Lili, Klein Corinna, Dellovade Tammy, Karran Eric
细胞生物学
Mouse
发表日期：2025
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Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs.

利用皮质类器官衍生的黑色素瘤脑转移微环境模型，可以对癌症靶向药物进行优先排序。

期刊:Cell Reports Methods
影响因子:4.5
doi:10.1016/j.crmeth.2025.101236
Krieg Kim, Materna-Reichelt Silvia, Naber Tobias, Rachad Fatima-Zahra, Kauven Pia, Weller Arjen, Haferkamp Undine, Wittich Annika, Zaliani Andrea, Woo Marcel S, Walkenhorst Mark, Siegmund Malte, Harberts Jann, Zierold Robert, Blick Robert, Conze Christian, Muschong Patricia, Miltner Dominik, Friese Manuel A, Mezler Mario, Siegmund Heiko, Evert Katja, Krasemann Susanne, Gužvić Nataša Stojanović, Klein Christoph A, Werner-Klein Melanie, Wegener Joachim, Pless Ole
黑色素瘤
肿瘤
肿瘤免疫
神经科学
3D/类器官
发表日期：2025
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Conquering the beyond Rule of Five Space with an Optimized High-Throughput Caco-2 Assay to Close Gaps in Absorption Prediction

利用优化的高通量Caco-2检测方法攻克“五规则”之外的领域，以弥补吸收预测方面的差距

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics16070846
Muschong, Patricia; Awwad, Khader; Price, Edward; Mezler, Mario; Weinheimer, Manuel
发表日期：2024
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Challenges in Permeability Assessment for Oral Drug Product Development

口服药物产品开发中渗透性评估的挑战

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics15102397
Koziolek, Mirko; Augustijns, Patrick; Berger, Constantin; Cristofoletti, Rodrigo; Dahlgren, David; Keemink, Janneke; Matsson, Pär; McCartney, Fiona; Metzger, Marco; Mezler, Mario; Niessen, Janis; Polli, James E; Vertzoni, Maria; Weitschies, Werner; Dressman, Jennifer
发表日期：2023
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Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery

利用靶向药物递送治疗中枢神经系统疾病的新进展

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics15041100
Meyer, Axel H; Feldsien, Thomas M; Mezler, Mario; Untucht, Christopher; Venugopalan, Ramakrishna; Lefebvre, Didier R
神经科学
发表日期：2023
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Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

利用粘蛋白保护的Caco-2细胞测定法研究复杂生物相关介质中药物的渗透性

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics14040699
Ye, Dong; López Mármol, Álvaro; Lenz, Verena; Muschong, Patricia; Wilhelm-Alkubaisi, Anita; Weinheimer, Manuel; Koziolek, Mirko; Sauer, Kerstin A; Laplanche, Loic; Mezler, Mario
细胞生物学
发表日期：2022
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Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion

收集小鼠间质脑液中的抗体和大分子生物标志物：微透析与脑开放流微灌注的比较

期刊:MAbs
影响因子:5.6
doi:10.1080/19420862.2021.1918819
Florie Le Prieult, Erica Barini, Loic Laplanche, Kerstin Schlegel, Mario Mezler
信号转导
Mouse
发表日期：2021
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Trafficking of JC virus-like particles across the blood-brain barrier

JC 病毒样颗粒穿过血脑屏障的运输

期刊:Nanoscale Advances
影响因子:4.6
doi:10.1039/d0na00879f
Dong Ye, Tina Zimmermann, Victoria Demina, Sergey Sotnikov, Christian L Ried, Harri Rahn, Marcus Stapf, Christopher Untucht, Michael Rohe, Georg C Terstappen, Karsten Wicke, Mario Mezler, Heiko Manninga, Axel H Meyer
免疫
微生物学
血脑屏障
发表日期：2021
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Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats

II 组代谢型谷氨酸受体正向变构调节剂 LY487379 对大鼠认知灵活性和冲动样反应的影响

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.1
doi:10.1124/jpet.110.170506
Agnieszka Nikiforuk, Piotr Popik, Karla U Drescher, Marcel van Gaalen, Ana-Lucia Relo, Mario Mezler, Gerard Marek, Hans Schoemaker, Gerhard Gross, Anton Bespalov
代谢
发表日期：2010
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Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist

阻断 mGluR1 受体可导致镇痛并损害运动和认知功能：新型非竞争性 mGluR1 受体拮抗剂 A-841720 的作用

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1038/sj.bjp.0706877
El-Kouhen, O; Lehto, S G; Pan, J B; Chang, R; Baker, S J; Zhong, C; Hollingsworth, P R; Mikusa, J P; Cronin, E A; Chu, K L; McGaraughty, S P; Uchic, M E; Miller, L N; Rodell, N M; Patel, M; Bhatia, P; Mezler, M; Kolasa, T; Zheng, G Z; Fox, G B; Stewart, A O; Decker, M W; Moreland, R B; Brioni, J D; Honore, P
信号转导
神经科学
发表日期：2006
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