日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism

骨细胞通过核受体 PPAR-alpha 维持骨骼和全身能量代谢

Amit Chougule, Sudipta Baroi, Piotr J Czernik, Emily Crowe, Mi Ra Chang, Patrick R Griffin, Beata Lecka-Czernik

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement

反应元件识别和共调节因子参与过程中 RORγ 的构象变化

Timothy S Strutzenberg, Yingmin Zhu, Scott J Novick, Ruben D Garcia-Ordonez, Christelle Doebelin, Yuanjun He, Mi Ra Chang, Theodore M Kamenecka, Dean P Edwards, Patrick R Griffin

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

HDX-MS 揭示了合成激动剂导致 RORγ 过度活化的结构决定因素

Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity

HDX-MS 揭示了在 RIG-I 介导的自身免疫过程中,失调的检查点会影响对自身 RNA 的识别

Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C Devarkar, Brandon Schweibenz, Gogce C Crynen, Ruben D Garcia-Ordonez, Bruce D Pascal, Scott J Novick, Smita S Patel, Joseph Marcotrigiano, Patrick R Griffin

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration

发现耐水解的异吲哚啉 N-酰基氨基酸类似物,可刺激线粒体呼吸

Hua Lin, Jonathan Z Long, Alexander M Roche, Katrin J Svensson, Florence Y Dou, Mi Ra Chang, Timothy Strutzenberg, Claudia Ruiz, Michael D Cameron, Scott J Novick, Charles A Berdan, Sharon M Louie, Daniel K Nomura, Bruce M Spiegelman, Patrick R Griffin, Theodore M Kamenecka

Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism

化学交联质谱揭示 PPARγ 活化螺旋的构象景观;配体依赖性拮抗作用的模型

Jie Zheng, Cesar Corzo, Mi Ra Chang, Jinsai Shang, Vinh Q Lam, Richard Brust, Anne-Laure Blayo, John B Bruning, Theodore M Kamenecka, Douglas J Kojetin, Patrick R Griffin

Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics

2,4-二氯-N-(3,5-二氯-4-(喹啉-3-基氧)苯基)苯磺酰胺 (INT131) 类似物作为 PPARγ 靶向抗糖尿病药物的构效关系

Rebecca L Frkic, Yuanjun He, Beatriz B Rodriguez, Mi Ra Chang, Dana Kuruvilla, Anthony Ciesla, Andrew D Abell, Theodore M Kamenecka, Patrick R Griffin, John B Bruning

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism

SR2067 揭示了 PPARγ 部分激动的独特动力学和结构特征

Laura M van Marrewijk, Steven W Polyak, Marcel Hijnen, Dana Kuruvilla, Mi Ra Chang, Youseung Shin, Theodore M Kamenecka, Patrick R Griffin, John B Bruning

Synthetic RORγt Agonists Enhance Protective Immunity

合成 RORγt 激动剂增强保护性免疫

Mi Ra Chang, Venkatasubramanian Dharmarajan, Christelle Doebelin, Ruben D Garcia-Ordonez, Scott J Novick, Dana S Kuruvilla, Theodore M Kamenecka, Patrick R Griffin

Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism

配体和受体动力学有助于 PPARγ 分级激动机制

Travis S Hughes, Michael J Chalmers, Scott Novick, Dana S Kuruvilla, Mi Ra Chang, Theodore M Kamenecka, Mark Rance, Bruce A Johnson, Thomas P Burris, Patrick R Griffin, Douglas J Kojetin