Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2
PI3Kα RAS结合域的共价抑制剂可抑制RAS和HER2驱动的肿瘤生长。
期刊:Science
影响因子:45.8
doi:10.1126/science.adv2684
Klebba, Joseph E; Roy, Nilotpal; Bernard, Steffen M; Grabow, Stephanie; Hoffman, Melissa A; Miao, Hui; Tamiya, Junko; Wang, Jinwei; Berry, Cynthia; Esparza-Oros, Antonio; Lin, Richard; Liu, Yongsheng; Pariollaud, Marie; Parker, Holly; Mochalkin, Igor; Rana, Sareena; Snead, Aaron N; Walton, Eric J; Wyrick, Taylor E; Aitichson, Erick; Bedke, Karl; Brannon, Jacyln C; Chick, Joel M; Hee, Kenneth; Horning, Benjamin D; Ismail, Mohamed; Lamb, Kelsey N; Lin, Wei; Lu, Justine; Pastuszka, Martha K; Pollock, Jonathan; Sigler, John J; Tomaschko, Mona; Tran, Eileen; Yue, Chanyu; Kinsella, Todd M; Molina-Arcas, Miriam; Cook, Brian N; Simon, Gabriel M; Weinstein, David S; Downward, Julian; Patricelli, Matthew P
