Apolipoprotein E promotes primary resistance to AR-targeted therapy via inducing TRIM25-mediated AR ubiquitination and sensitizes immunotherapy in prostate cancer
载脂蛋白E通过诱导TRIM25介导的雄激素受体(AR)泛素化促进对AR靶向治疗的原发性耐药,并增强前列腺癌对免疫疗法的敏感性。
期刊:Theranostics
影响因子:13.3
doi:10.7150/thno.109994
Liu, Chaofan; Wang, Xi; Li, Qinyu; Gao, Xintao; Zeng, Kai; Li, Beining; Miao, Jianping; Zheng, Bolong; Liu, Jihong; Wang, Zhihua; Yuan, Xianglin; Liu, Bo
肿瘤
表观遗传
肿瘤免疫
信号转导
泛素化
前列腺癌
免疫/内分泌