日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

发现一种具有免疫治疗活性的首创共价变构SHP1抑制剂

Qu, Zihan; Meke, Frederick Nguele; Zhang, Zheng; Krabill, Aaron D; Muli, Christine S; Jassim, Brenson A; Dong, Jiajun; Nguyen, Quyen D; Bai, Yunpeng; Li, Jinyue; Miao, Yiming; Asadi, Bardia; Johnson, Levi M; Miao, Jinmin; Trader, Darci J; Tao, W Andy; Zhang, Zhong-Yin

Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase

发现和评价活性位点导向的、高效、选择性磺基苯乙酸酰胺类拉福林磷酸酶抑制剂

Lin, Jianping; He, Rongjun; Qu, Zihan; Dong, Jiajun; Krabill, Aaron D; Wu, Li; Bai, Yunpeng; Conroy, Lindsey R; Bruntz, Ronald C; Miao, Yiming; Jassim, Brenson A; Babalola, Benjamin; Nguele Meke, Frederick Georges Bernard; Sun, Ramon; Gentry, Matthew S; Zhang, Zhong-Yin

The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor.

PRL2 磷酸酶通过激活 JAK2/STAT3 通路上调 miR-21,从而下调 PTEN 肿瘤抑制因子

Li Qinglin, Bai Yunpeng, Cavender Sarah M, Miao Yiming, Nguele Meke Frederick, Lasse-Opsahl Emily L, Zhu Peipei, Doody Gina M, Tao W Andy, Zhang Zhong-Yin

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.

开发新型含膦二氟甲基的磷酸酪氨酸模拟物,以及首创的高效、选择性和生物利用度高的CDC14磷酸酶抑制剂

Dong Jiajun, Jassim Brenson A, Milholland Kedric L, Qu Zihan, Bai Yunpeng, Miao Yiming, Miao Jinmin, Ma Yuan, Lin Jianping, Hall Mark C, Zhang Zhong-Yin

Impact of blade direction on postoperative femoral head varus in PFNA fixed patients: a clinical review and biomechanical research

刀片方向对PFNA固定术后股骨头内翻的影响:临床回顾和生物力学研究

Xu, Yue; Zhang, Xiaoyu; Li, Jingchi; Miao, Yiming; Ying, Pu; Chen, Cong; Xu, Wenqiang; Wang, Qiang

Exacerbation of allergic rhinitis by the commensal bacterium Streptococcus salivarius

共生菌唾液链球菌加剧过敏性鼻炎

Ping Miao #, Yiming Jiang #, Ying Jian #, Jiali Shi, Yao Liu, Pipat Piewngam, Yue Zheng, Gordon Y C Cheung, Qian Liu, Michael Otto, Min Li

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy

用于癌症免疫治疗的小分子蛋白酪氨酸磷酸酶1B和T细胞蛋白酪氨酸磷酸酶降解剂

Dong, Jiajun; Miao, Jinmin; Miao, Yiming; Qu, Zihan; Zhang, Sheng; Zhu, Peipei; Wiede, Florian; Jassim, Brenson A; Bai, Yunpeng; Nguyen, Quyen; Lin, Jianping; Chen, Lan; Tiganis, Tony; Tao, W Andy; Zhang, Zhong-Yin

Discovery of a selective TC-PTP degrader for cancer immunotherapy

发现一种用于癌症免疫治疗的选择性TC-PTP降解剂

Miao, Jinmin; Dong, Jiajun; Miao, Yiming; Bai, Yunpeng; Qu, Zihan; Jassim, Brenson A; Huang, Bo; Nguyen, Quyen; Ma, Yuan; Murray, Allison A; Li, Jinyue; Low, Philip S; Zhang, Zhong-Yin

CCL7 and TGF-β secreted by MSCs play opposite roles in regulating CRC metastasis in a KLF5/CXCL5-dependent manner

间充质干细胞分泌的CCL7和TGF-β在KLF5/CXCL5依赖性调控结直肠癌转移中发挥相反的作用。

Xu, Zhuoqing; Gao, Han; Zhang, Yuchen; Feng, Wenqing; Miao, Yiming; Xu, Zifeng; Li, Wenchang; Chen, Fangqian; Lv, Zeping; Huo, Jianting; Liu, Wangyi; Shen, Xiaohui; Zong, Yaping; Zhao, Jingkun; Lu, Aiguo

KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response

KLF5抑制剂通过恢复细胞凋亡反应克服了患者来源的结直肠癌类器官的奥沙利铂耐药性。

Shen, Xiaohui; Zhang, Yuchen; Xu, Zhuoqing; Gao, Han; Feng, Wenqing; Li, Wenchang; Miao, Yiming; Xu, Zifeng; Zong, Yaping; Zhao, Jingkun; Lu, Aiguo