日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

来自 Apc 突变细胞的 NOTUM 蛋白会偏向克隆竞争,从而引发癌症。

Dustin J Flanagan ,Nalle Pentinmikko ,Kalle Luopajärvi ,Nicky J Willis ,Kathryn Gilroy ,Alexander P Raven ,Lynn Mcgarry ,Johanna I Englund ,Anna T Webb ,Sandra Scharaw ,Nadia Nasreddin ,Michael C Hodder ,Rachel A Ridgway ,Emma Minnee ,Nathalie Sphyris ,Ella Gilchrist ,Arafath K Najumudeen ,Beatrice Romagnolo ,Christine Perret ,Ann C Williams ,Hans Clevers ,Pirjo Nummela ,Marianne Lähde ,Kari Alitalo ,Ville Hietakangas ,Ann Hedley ,William Clark ,Colin Nixon ,Kristina Kirschner ,E Yvonne Jones ,Ari Ristimäki ,Simon J Leedham ,Paul V Fish ,Jean-Paul Vincent ,Pekka Katajisto ,Owen J Sansom

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

致癌基因 BRAF 不受 TGFβ 受体信号传导的限制,可驱动右侧结肠肿瘤发生

Joshua D G Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A Ridgway, Dustin J Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G Vázquez, David F Vincent, William J Faller, Michael C Hodder, Alexander Raven, Sigrid Fey, Arafath K Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Cla

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

RAL GTPases 通过 WNT 信号体的内化来驱动肠道干细胞的功能和再生

Joel Johansson, Mate Naszai, Michael C Hodder, Karen A Pickering, Bryan W Miller, Rachel A Ridgway, Yachuan Yu, Pascal Peschard, Saskia Brachmann, Andrew D Campbell, Julia B Cordero, Owen J Sansom

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

在重现人类癌症的模型中,BCL9/9l 的缺失会抑制 Wnt 驱动的肿瘤发生

David M Gay, Rachel A Ridgway, Miryam Müller, Michael C Hodder, Ann Hedley, William Clark, Joshua D Leach, Rene Jackstadt, Colin Nixon, David J Huels, Andrew D Campbell, Thomas G Bird, Owen J Sansom

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

TGFβ 通路限制 WNT 和 MAPK 通路激活后的去分化,从而抑制肠道肿瘤发生

Patrizia Cammareri, David F Vincent, Michael C Hodder, Rachel A Ridgway, Claudio Murgia, Max Nobis, Andrew D Campbell, Julia Varga, David J Huels, Chithra Subramani, Katie L H Prescott, Colin Nixon, Ann Hedley, Simon T Barry, Florian R Greten, Gareth J Inman, Owen J Sansom