日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

抑制p53-MDM2结合可减少衰老细胞数量,并改善老年小鼠骨骼肌的适应性反应。

Georgia L Nolt,Alexander R Keeble,Yuan Wen ,Aubrey C Strong,Nicholas T Thomas ,Taylor R Valentino,Camille R Brightwell ,Kevin A Murach,Sini Patrizia,Harald Weinstabl,Andreas Gollner,John J McCarthy,Christopher S Fry ,Michael Franti,Antonio Filareto,Charlotte A Peterson ,Cory M Dungan

A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice

一种新型线粒体复合物 I ROS 抑制剂可部分改善成年小鼠的肌肉再生,但对老年小鼠无作用

Gavin Pharaoh, Ethan L Ostrom, Rudy Stuppard, Matthew Campbell, Jens Markus Borghardt, Michael Franti, Antonio Filareto, David J Marcinek

Deletion of SA β-Gal+ cells using senolytics improves muscle regeneration in old mice

利用衰老细胞清除剂清除 SA β-半乳糖苷酶阳性细胞可改善老年小鼠的肌肉再生。

Cory M Dungan ,Kevin A Murach ,Christopher J Zdunek ,Zuo Jian Tang ,Georgia L Nolt ,Camille R Brightwell ,Zachary Hettinger ,Davis A Englund ,Zheng Liu ,Christopher S Fry ,Antonio Filareto ,Michael Franti ,Charlotte A Peterson

The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

Klotho 对衰老特征和骨骼肌功能的双相和年龄依赖性影响

Zachary Clemens #, Sruthi Sivakumar #, Abish Pius #, Amrita Sahu, Sunita Shinde, Hikaru Mamiya, Nathaniel Luketich, Jian Cui, Purushottam Dixit, Joerg D Hoeck, Sebastian Kreuz, Michael Franti, Aaron Barchowsky, Fabrisia Ambrosio

Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis

通过单细胞转录组分析表征链脲佐菌素模型中的胰腺 β 细胞异质性

Ye Feng, Wei-Lin Qiu, Xin-Xin Yu, Yu Zhang, Mao-Yang He, Lin-Chen Li, Li Yang, Weiyi Zhang, Michael Franti, Junqing Ye, Joerg D Hoeck, Cheng-Ran Xu

Klotho: An Elephant in Aging Research

克洛索:衰老研究中的大象

Amin Cheikhi, Aaron Barchowsky, Amrita Sahu, Sunita N Shinde, Abish Pius, Zachary J Clemens, Hua Li, Charles A Kennedy, Joerg D Hoeck, Michael Franti, Fabrisia Ambrosio

High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions

高通量小干扰 RNA 筛选鉴定出磷脂酰肌醇 3-激酶 II 类 Alpha 对人类巨细胞病毒病毒体的产生至关重要

William S Polachek, Hanan F Moshrif, Michael Franti, Donald M Coen, Vattipally B Sreenu, Blair L Strang

Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo

磷脂酰肌醇 4-激酶 III β 对人类鼻病毒的复制至关重要,其抑制会导致体内致死表型

Catherine Spickler, Julie Lippens, Marie-Kristine Laberge, Sophie Desmeules, Édith Bellavance, Michel Garneau, Tim Guo, Oliver Hucke, Pieter Leyssen, Johan Neyts, Fréderic H Vaillancourt, Anne Décor, Jeff O'Meara, Michael Franti, Annick Gauthier

Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein

使用与 HIV-1 包膜糖蛋白交联的 CD4 模拟物诱发针对 CD4 诱导表位的中和抗体

Antu K Dey, Brian Burke, Yide Sun, Klara Sirokman, Avishek Nandi, Karin Hartog, Ying Lian, Anthony R Geonnotti, David Montefiori, Michael Franti, Grégoire Martin, Andrea Carfi, Pascal Kessler, Loïc Martin, Indresh K Srivastava, Susan W Barnett

Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1

源自 A 亚型 HIV-1 的裂解、稳定包膜三聚体的结构和免疫原性研究

Yun Kenneth Kang, Sofija Andjelic, James M Binley, Emma T Crooks, Michael Franti, Sai Prasad N Iyer, Gerald P Donovan, Antu K Dey, Ping Zhu, Kenneth H Roux, Robert J Durso, Thomas F Parsons, Paul J Maddon, John P Moore, William C Olson