日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env

通过与 HIV-1 包膜顶端的相互作用调节 gp41 膜近端外部区域的表位暴露

Hannah M Schapiro, Mukta D Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Maria E Cilento, Michael J Root

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

改变环境构象动力学作为对肽三唑 HIV-1 灭活剂产生抗性的机制

Shiyu Zhang #, Andrew P Holmes #, Alexej Dick, Adel A Rashad, Lucía Enríquez Rodríguez, Gabriela A Canziani, Michael J Root, Irwin M Chaiken

Characterization of resistance to a potent D-peptide HIV entry inhibitor

对强效 D 肽 HIV 进入抑制剂的抗性表征

Amanda R Smith, Matthew T Weinstock, Amanda E Siglin, Frank G Whitby, J Nicholas Francis, Christopher P Hill, Debra M Eckert, Michael J Root, Michael S Kay

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

位点特异性聚合物与针对 HIV-1 的 HR2 肽融合抑制剂的结合降低了结合速率和解离速率,而不是结合亲和力

Maarten Danial, Angela N Stauffer, Frederik R Wurm, Michael J Root, Harm-Anton Klok

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

与 CXCR4 氨基末端结合的 gp41 七肽重复序列 2 结构域肽对 HIV-1 具有强效和广泛的抑制作用

George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie

Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance

设计一种具有强抗药性屏障的强效 D 肽 HIV-1 进入抑制剂

Brett D Welch, J Nicholas Francis, Joseph S Redman, Suparna Paul, Matthew T Weinstock, Jacqueline D Reeves, Yolanda S Lie, Frank G Whitby, Debra M Eckert, Christopher P Hill, Michael J Root, Michael S Kay

Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain

通过针对催化轻链的特异性人单克隆抗体中和肉毒杆菌毒素

Sharad P Adekar, Tsuyoshi Takahashi, R Mark Jones, Fetweh H Al-Saleem, Denise M Ancharski, Michael J Root, B P Kapadnis, Lance L Simpson, Scott K Dessain

Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein

将疗法靶向 HIV-1 融合蛋白中暴露且保守的结合元件

Michael J Root, Dean H Hamer