日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SAR443809: a selective inhibitor of the complement alternative pathway, targeting complement factor Bb

SAR443809:补体旁路选择性抑制剂,靶向补体因子 Bb

Vaishnavi Rajagopal, Nina Leksa, Ronald Gorham, Siddharth Jindal, Soumya Nair, Kevin Knockenhauer, Joanne Chan, Tony Byun, Courtney Mercadante, Stephen Moore, Sandip Panicker, Graham Parry, Michael Storek

Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue

开发和优化双功能融合蛋白以局部调节病变组织中的补体激活

Kelly C Fahnoe ,Fei Liu ,Jennifer G Morgan ,Sarah T Ryan ,Michael Storek ,Ellen Garber Stark ,Fred R Taylor ,V Michael Holers ,Joshua M Thurman ,Stefan Wawersik ,Susan L Kalled ,Shelia M Violette

The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models

人类补体受体 2 型 (CR2)/CR1 融合蛋白 TT32 是经典和替代途径 C3 转化酶的新型靶向抑制剂,可在主动免疫和被动转移小鼠模型中预防关节炎

Masha Fridkis-Hareli, Michael Storek, Eran Or, Richard Altman, Suresh Katti, Fang Sun, Tao Peng, Jeff Hunter, Krista Johnson, Yi Wang, Ante S Lundberg, Gaurav Mehta, Nirmal K Banda, V Michael Holers

Immune reconstitution after anti-thymocyte globulin-conditioned hematopoietic cell transplantation

抗胸腺细胞球蛋白预处理的造血干细胞移植后的免疫重建

Bosch, Mark; Dhadda, Manveer; Hoegh-Petersen, Mette; Liu, Yiping; Hagel, Laura M; Podgorny, Peter; Ugarte-Torres, Alejandra; Khan, Faisal M; Luider, Joanne; Auer-Grzesiak, Iwona; Mansoor, Adnan; Russell, James A; Daly, Andrew; Stewart, Douglas A; Maloney, David; Boeckh, Michael; Storek, Jan

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

TT30 的设计和开发,一种新型 C3d 靶向 C3/C5 转化酶抑制剂,用于治疗人类补体替代途径介导的疾病

Masha Fridkis-Hareli, Michael Storek, Istvan Mazsaroff, Antonio M Risitano, Ante S Lundberg, Christopher J Horvath, V Michael Holers