日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

一种罕见的人类百岁老人SIRT6变异体增强了基因组稳定性和与层粘蛋白A的相互作用。

Matthew Simon #,Jiping Yang #,Jonathan Gigas,Eric J Earley,Eric Hillpot,Lei Zhang,Maria Zagorulya,Greg Tombline,Michael Gilbert,Samantha L Yuen,Alexis Pope,Michael Van Meter,Stephan Emmrich,Denis Firsanov,Advait Athreya,Seyed Ali Biashad,Jeehae Han,Seungjin Ryu,Archana Tare,Yizhou Zhu,Adam Hudgins,Gil Atzmon,Nir Barzilai,Aaron Wolfe,Kelsey Moody,Benjamin A Garcia,David D Thomas,Paul D Robbins,Jan Vijg,Andrei Seluanov,Yousin Suh,Vera Gorbunova

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

LINE1在老年野生型和SIRT6缺陷型小鼠中的去抑制驱动炎症

Matthew Simon ,Michael Van Meter ,Julia Ablaeva ,Zhonghe Ke ,Raul S Gonzalez ,Taketo Taguchi ,Marco De Cecco ,Katerina I Leonova ,Valeria Kogan ,Stephen L Helfand ,Nicola Neretti ,Asael Roichman ,Haim Y Cohen ,Margarita V Meer ,Vadim N Gladyshev ,Marina P Antoch ,Andrei V Gudkov ,John M Sedivy ,Andrei Seluanov ,Vera Gorbunova

Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia

在自发性遗传异质性 T 细胞急性淋巴细胞白血病小鼠模型中,针对 Notch 信号和免疫检查点阻断进行治疗

Jie Gao, Michael Van Meter, Susana Hernandez Lopez, Guoying Chen, Ying Huang, Shumei Ren, Qi Zhao, Jose Rojas, Cagan Gurer, Gavin Thurston, Frank Kuhnert

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

JNK 磷酸化 SIRT6,通过募集 PARP1 到 DNA 断裂处来刺激 DNA 双链断裂修复,以应对氧化应激

Michael Van Meter, Matthew Simon, Gregory Tombline, Alfred May, Timothy D Morello, Basil P Hubbard, Katie Bredbenner, Rosa Park, David A Sinclair, Vilhelm A Bohr, Vera Gorbunova, Andrei Seluanov

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

SIRT6 以 PARP1 依赖的方式挽救与年龄相关的碱基切除修复功能下降。

Zhu Xu ,Lei Zhang, Wenjun Zhang, Du Meng, Hongxia Zhang, Ying Jiang, Xiaojun Xu, Michael Van Meter, Andrei Seluanov, Vera Gorbunova, Zhiyong Mao

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

SIRT6 通过核糖基化 KAP1 来抑制 LINE1 逆转录转座子,但这种抑制会随着压力和年龄的增长而失效

Michael Van Meter, Mehr Kashyap, Sarallah Rezazadeh, Anthony J Geneva, Timothy D Morello, Andrei Seluanov, Vera Gorbunova

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

Sirtuin 6 (SIRT6) 挽救复制衰老过程中同源重组修复的衰退

Zhiyong Mao, Xiao Tian, Michael Van Meter, Zhonghe Ke, Vera Gorbunova, Andrei Seluanov

Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways

舒尼替尼通过抑制STAT3和AKT信号通路诱导髓母细胞瘤细胞凋亡和生长停滞。

Yang, Fan; Jove, Veronica; Xin, Hong; Hedvat, Michael; Van Meter, Timothy E; Yu, Hua