日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing

解码甘露糖受体-mAb 相互作用:高甘露糖 N-糖和糖配对的重要性

Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M J Aertker, Fabian Higel

Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies

探索 IgG1-scFv 双特异性抗体的分子决定因素和药代动力学特性

Kristina M J Aertker, Minu Ravindra Pilvankar, Tobias M Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

单克隆抗体的合理优化可改善聚集倾向并增强整个制药工艺链中的 CMC 特性

Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick

Prediction and Reduction of the Aggregation of Monoclonal Antibodies

单克隆抗体聚集的预测和减少

Rob van der Kant, Anne R Karow-Zwick, Joost Van Durme, Michaela Blech, Rodrigo Gallardo, Daniel Seeliger, Kerstin Aßfalg, Pieter Baatsen, Griet Compernolle, Ann Gils, Joey M Studts, Patrick Schulz, Patrick Garidel, Joost Schymkowitz, Frederic Rousseau

Boosting antibody developability through rational sequence optimization

通过合理的序列优化提高抗体的可开发性

Daniel Seeliger, Patrick Schulz, Tobias Litzenburger, Julia Spitz, Stefan Hoerer, Michaela Blech, Barbara Enenkel, Joey M Studts, Patrick Garidel, Anne R Karow