日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Correction to "Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties"

对“具有改进药理特性的强效、选择性吡咯并嘧啶PDE11A4抑制剂”的更正

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.6c00150
Mahmood, Shams Ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P; Rotella, David P
发表日期：2026
文献求助 收藏

Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties

具有改进药理特性的高效、选择性吡咯并嘧啶类PDE11A4抑制剂

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00756
Mahmood, Shams Ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P; Rotella, David P
发表日期：2026
文献求助 收藏

Age-Related Upregulation and Strong Expression Correlation of the Proinflammatory Cytokines IL-1β and IL-6 Across Multiple Segments of the Mouse Eye

小鼠眼部多个节段中促炎细胞因子IL-1β和IL-6的表达随年龄增长而上调，且二者表达呈强相关性。

期刊:
影响因子:
doi:10.64898/2026.01.09.698735
Greene, Haley; Sbornova, Irina; Kelly, Michy P
免疫/内分泌
细胞生物学
Mouse
IL-6
IL-1β
发表日期：2026
文献求助 收藏

Cyclic nucleotide phosphodiesterases as drug targets

环核苷酸磷酸二酯酶作为药物靶点

期刊:Pharmacological Reviews
影响因子:17.3
doi:10.1016/j.pharmr.2025.100042
Kelly, Michy P; Nikolaev, Viacheslav O; Gobejishvili, Leila; Lugnier, Claire; Hesslinger, Christian; Nickolaus, Peter; Kass, David A; Pereira de Vasconcelos, Walma; Fischmeister, Rodolphe; Brocke, Stefan; Epstein, Paul M; Piazza, Gary A; Keeton, Adam B; Zhou, Gang; Abdel-Halim, Mohammad; Abadi, Ashraf H; Baillie, George S; Giembycz, Mark A; Bolger, Graeme; Snyder, Gretchen; Tasken, Kjetil; Saidu, Nathaniel E B; Schmidt, Martina; Zaccolo, Manuela; Schermuly, Ralph T; Ke, Hengming; Cote, Rick H; Mohammadi Jouabadi, Soroush; Roks, Anton J M
发表日期：2025
文献求助 收藏

Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors.

与年龄相关的 PDE11A4 蛋白表达增加会引发该酶的液-液相分离 (LLPS)，而 PDE11A4 小分子抑制剂可以逆转这一现象

期刊:Cells
影响因子:5.2
doi:10.3390/cells14120897
Amurrio Elvis, Patel Janvi H, Danaher Marie, Goodwin Madison, Kargbo Porschderek, Klimentova Eliska, Lin Sonia, Kelly Michy P
其它
发表日期：2025
文献求助 收藏

First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders

首次证实体内PDE11A4靶点结合可用于治疗与年龄相关的记忆障碍

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01794
Mahmood, Shams Ul; Eberhard, Jeremy; Hoffman, Charles S; Colussi, Dennis; Gordon, John; Childers, Wayne; Amurrio, Elvis; Patel, Janvi; Kelly, Michy P; Rotella, David P
发表日期：2024
文献求助 收藏

The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme

与睡眠质量和近视相关的 PDE11A-Y727C 变异通过降低催化活性和改变酶的亚细胞区室化来影响神经生理

期刊:Cells
影响因子:5.1
doi:10.3390/cells12242839
Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D Burbano, Prosun K Das, Helen H Do, Janet L Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I De Zeeuw, Magda A Meester-Smoor, Beerend H J Winkelman, Caroline C W Klaver, Ana Pocivavsek, Michy P Kell
神经
其它细胞
IHC
Goat
IgY
发表日期：2023
文献求助 收藏

Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice

破坏海马 CA1 区 PDE11A4 同型二聚化的生物制剂可逆转小鼠因年龄相关而出现的社交记忆认知衰退

期刊:Neurobiology of Aging
影响因子:3.7
doi:10.1016/j.neurobiolaging.2023.07.008
Katy Pilarzyk, William R Capell, Latarsha Porcher, Audrey Rips-Goodwin, Michy P Kelly
信号转导
Most
Hippo
Goat
IgG
发表日期：2023
文献求助 收藏

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

与睡眠质量和近视相关的 PDE11A-Y727C 变异通过降低催化活性和改变酶的亚细胞区室化来影响神经生理

期刊:
影响因子:
doi:10.1101/2023.11.16.567422
Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D Burbano, Prosun Das, Helen Do, Janet L Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I De Zeeuw, Magda A Meester-Smoor, Beerend H J Winkelman, Caroline C W Klaver, Ana Pocivavsek, Michy P Kelly
神经
其它细胞
IHC
Goat
IgY
发表日期：2023
文献求助 收藏

Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories

海马体中PDE11A4的保守性年龄相关性增加会导致意想不到的蛋白病变和社交联想记忆的认知衰退。

期刊:Aging Cell
影响因子:7.1
doi:10.1111/acel.13687
Pilarzyk, Katy; Porcher, Latarsha; Capell, William R; Burbano, Steven D; Davis, Jeff; Fisher, Janet L; Gorny, Nicole; Petrolle, Siena; Kelly, Michy P
神经科学
发表日期：2022
文献求助 收藏