日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis.

OT-82 是一种新型抗癌候选药物,它针对血液恶性肿瘤对 NAD 生物合成的强烈依赖性

Korotchkina Lioubov, Kazyulkin Denis, Komarov Pavel G, Polinsky Alex, Andrianova Ekaterina L, Joshi Sangeeta, Gupta Mahima, Vujcic Slavoljub, Kononov Eugene, Toshkov Ilia, Tian Yuan, Krasnov Peter, Chernov Mikhail V, Veith Jean, Antoch Marina P, Middlemiss Shiloh, Somers Klaartje, Lock Richard B, Norris Murray D, Henderson Michelle J, Haber Michelle, Chernova Olga B, Gudkov Andrei V

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

一种新型小分子,可通过诱导线粒体功能障碍杀死一部分MLL重排的白血病细胞。

Somers, Klaartje; Wen, Victoria W; Middlemiss, Shiloh M C; Osborne, Brenna; Forgham, Helen; Jung, MoonSun; Karsa, Mawar; Clifton, Molly; Bongers, Angelika; Gao, Jixuan; Mayoh, Chelsea; Raoufi-Rad, Newsha; Kusnadi, Eric P; Hannan, Kate M; Scott, David A; Kwek, Alan; Liu, Bing; Flemming, Claudia; Chudakova, Daria A; Pandher, Ruby; Failes, Tim W; Lim, James; Angeli, Andrea; Osterman, Andrei L; Imamura, Toshihiko; Kees, Ursula R; Supuran, Claudiu T; Pearson, Richard B; Hannan, Ross D; Davis, Thomas P; McCarroll, Joshua; Kavallaris, Maria; Turner, Nigel; Gudkov, Andrei V; Haber, Michelle; Norris, Murray D; Henderson, Michelle J