日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Road map for primary hepatocyte qualification in human liver organ models

人类肝脏器官模型中原代肝细胞鉴定的路线图

Varmazyad, Mahboubeh; Gavlock, Dillon C; Castiglione, Michael W; DeBiasio, Richard; LaRocca, Gregory; Reese, Celeste; Vernetti, Lawrence A; Schurdak, Mark; Stern, Andrew M; Taylor, D Lansing; Miedel, Mark T; Brown, Jacquelyn A

Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant

基于人诱导多能干细胞的脂质代谢相关TM6SF2-E167K变体肝脏模型

Faccioli, Lanuza A P; Sun, Yiyue; Animasahun, Olamide; Motomura, Takashi; Liu, Zhenghao; Kurihara, Takeshi; Hu, Zhiping; Yang, Bo; Cetin, Zeliha; Baratta, Annalisa M; Shankaran, Ajay; Nenwani, Minal; Altay, Leyla Nurcihan; Huang, Linqi; Meurs, Noah; Franks, Jonathan; Stolz, Donna; Gavlock, Dillon C; Miedel, Mark T; Ostrowska, Alina; Florentino, Rodrigo M; Fox, Ira J; Nagrath, Deepak; Soto-Gutierrez, Alejandro

PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes

PNPLA3-I148M基因变异重塑脂质代谢,从而驱动人类肝细胞程序性细胞死亡

Florentino, Rodrigo M; Animasahun, Olamide; Haep, Nils; Nenwani, Minal; Omoloja, Kehinde; Altay, Leyla Nurcihan; Achreja, Abhinav; Morita, Kazutoyo; Motomura, Takashi; Diaz-Aragon, Ricardo; Faccioli, Lanuza Ap; Sun, Yiyue; Liu, Zhenghao; Hu, Zhiping; Yang, Bo; Wuchu, Fulei; Shankaran, Ajay; Paserba, Miya; Baratta, Annalisa M; Arazov, Shohrat; Kocas-Kilicarslan, Zehra N; Meurs, Noah; Behari, Jaideep; Tafaleng, Edgar N; Franks, Jonathan; Ostrowska, Alina; Tomiyama, Takahiro; Yugawa, Kyohei; Morinaga, Akinari; Wang, Zi; Takeishi, Kazuki; Gavlock, Dillon C; Miedel, Mark; Taylor, D Lansing; Fox, Ira J; Yoshizumi, Tomoharu; Nagrath, Deepak; Soto-Gutierrez, Alejandro

Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata

验证用于解释患者异质性的微生理系统需要可靠的可重复性分析和实验元数据。

Miedel, Mark T; Varmazyad, Mahboubeh; Xia, Mengying; Brooks, Maria Mori; Gavlock, Dillon C; Reese, Celeste; Behari, Jaideep; Soto-Gutierrez, Alejandro; Gough, Albert; Taylor, D Lansing; Schurdak, Mark E

Underlying reasons for sex difference in survival following out-of-hospital cardiac arrest: a mediation analysis

院外心脏骤停后生存率性别差异的根本原因:一项中介分析

Miedel, Charlotte; Jonsson, Martin; Dragas, Mariana; Djärv, Therese; Nordberg, Per; Rawshani, Araz; Claesson, Andreas; Forsberg, Sune; Nord, Anette; Herlitz, Johan; Riva, Gabriel

A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

一种与代谢功能障碍相关的脂肪肝腺泡仿生模型在耦合微生理系统中诱导胰岛功能障碍。

Julio Aleman # ,Ravikumar K # ,Connor Wiegand # ,Mark E Schurdak ,Lawrence Vernetti ,Dillon Gavlock ,Celeste Reese ,Richard DeBiasio ,Greg LaRocca ,Yulder Daniel Angarita ,Albert Gough ,Alejandro Soto-Gutierrez ,Jaideep Behari ,Vijay K Yechoor ,Mark T Miedel ,Andrew M Stern ,Ipsita Banerjee ,D Lansing Taylor

Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy

在人体仿生肝脏微生理系统中比较野生型和高风险PNPLA3变异体,以用于代谢功能障碍相关脂肪肝疾病的精准治疗。

Mengying Xia # ,Mahboubeh Varmazyad # ,Iris Pla-Palacín # ,Dillon C Gavlock ,Richard DeBiasio ,Gregory LaRocca ,Celeste Reese ,Rodrigo M Florentino ,Lanuza A P Faccioli ,Jacquelyn A Brown ,Lawrence A Vernetti ,Mark Schurdak ,Andrew M Stern ,Albert Gough ,Jaideep Behari ,Alejandro Soto-Gutierrez ,D Lansing Taylor # ,Mark T Miedel #

Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease

与代谢功能障碍相关的脂肪肝疾病相关的多态性会影响终末期肝病的进展

Kocas-Kilicarslan, Zehra N; Cetin, Zeliha; Faccioli, Lanuza A P; Motomura, Takashi; Amirneni, Sriram; Diaz-Aragon, Ricardo; Florentino, Rodrigo M; Sun, Yiyue; Pla-Palacin, Iris; Xia, Mengying; Miedel, Mark T; Kurihara, Takeshi; Hu, Zhiping; Ostrowska, Alina; Wang, Zi; Constantine, Robert; Li, Albert; Taylor, D Lansing; Behari, Jaideep; Soto-Gutierrez, Alejandro; Tafaleng, Edgar N

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

人体仿生肝脏微生理系统与大分子定量系统毒理学 (QST) 建模平台 BIOLOGXsym 的结合,为了解托珠单抗和 GGF2 诱发的肝损伤机制提供了依据

James J Beaudoin, Lara Clemens, Mark T Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K M Shoda, Scott Q Siler, D Lansing Taylor, Brett A Howell, Lawrence A Vernetti, Kyunghee Yang

Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants

携带高风险或保护相关肝病遗传变异的人类肝细胞药物代谢评估

Lanuza A P Faccioli, Zeliha Cetin, Zehra N Kocas-Kilicarslan, Kimberly Ortiz, Yiyue Sun, Zhiping Hu, Takeshi Kurihara, Edgar N Tafaleng, Rodrigo M Florentino, Zi Wang, Mengying Xia, Mark T Miedel, D Lansing Taylor, Jaideep Behari, Alina Ostrowska, Robert Constantine, Albert Li, Alejandro Soto-Gutier