Gut microbial metabolite butyrate boosts p53-expressing telomerase-specific oncolytic adenovirus efficacy by enhancing infectivity and activating MHC-I/cGAS-STING.
肠道微生物代谢产物丁酸盐通过增强感染性和激活 MHC-I/cGAS-STING 来提高表达 p53 的端粒酶特异性溶瘤腺病毒的功效。
期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-025-04252-4
Sakamoto Masaki, Kuroda Shinji, Katayama Tetsuya, Mikane Yu, Hanzawa Shunya, Kadowaki Daisuke, Yoshida Yusuke, Hamada Yuki, Sugimoto Ryoma, Yagi Chiaki, Hashimoto Masashi, Kanaya Nobuhiko, Kakiuchi Yoshihiko, Kikuchi Satoru, Shigeyasu Kunitoshi, Tazawa Hiroshi, Kagawa Shunsuke, Urata Yasuo, Fujiwara Toshiyoshi
肠癌
微生物学
P53
CGA
CGAS
STING
cGAS-STING
