日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

基于表观遗传学的急性髓系白血病分化疗法

Edurne San José-Enériz # ,Naroa Gimenez-Camino # ,Obdulia Rabal ,Leire Garate ,Estibaliz Miranda ,Nahia Gómez-Echarte ,Fernando García ,Stella Charalampopoulou ,Elena Sáez ,Amaia Vilas-Zornoza ,Patxi San Martín-Uriz ,Luis V Valcárcel ,Naroa Barrena ,Diego Alignani ,Luis Esteban Tamariz-Amador ,Ana Pérez-Ruiz ,Sebastian Hilscher ,Mike Schutkowski ,Ana Alfonso-Pierola ,Nicolás Martinez-Calle ,María José Larrayoz ,Bruno Paiva ,María José Calasanz ,Javier Muñoz ,Marta Isasa ,José Ignacio Martin-Subero ,Antonio Pineda-Lucena ,Julen Oyarzabal ,Xabier Agirre ,Felipe Prósper

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

新型羟肟酸衍生物诱导白血病细胞凋亡并抑制自噬

Marten A Fischer, Al-Hassan M Mustafa, Kristin Hausmann, Ramy Ashry, Anita G Kansy, Magdalena C Liebl, Christina Brachetti, Andrea Piée-Staffa, Matthes Zessin, Hany S Ibrahim, Thomas G Hofmann, Mike Schutkowski, Wolfgang Sippl, Oliver H Krämer

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

开发一流的双重 Sirt2/HDAC6 抑制剂作为双重抑制微管蛋白去乙酰化的分子工具

Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z Yesiloglu, Sebastian Hilscher, Lena Gaitzsch, Niklas Papenkordt, Shiyang Zhai, Lin Zhang, Christophe Romier, Oliver Einsle, Wolfgang Sippl, Mike Schutkowski, Ol

1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors

1,3-二苯脲基异羟肟酸酯是一种有前途的支架,可用于生成有效的抗疟组蛋白去乙酰化酶抑制剂

Maurício T Tavares #, Arne Krüger #, Sun L Rei Yan, Karoline B Waitman, Vinícius M Gomes, Daffiny Sumam de Oliveira, Franciarli Paz, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Claudia Ruiz, Mônica F Z J Toledo, Neuza M A Hassimotto, João A Machado-Neto, Antti Poso, Michael D Cameron, Thom

Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6)

组蛋白去乙酰化酶 6 (HDAC6) 水解恶二唑类抑制剂的综合机制观察

Lucia Motlová, Ivan Šnajdr, Zsófia Kutil, Erik Andris, Jakub Ptáček, Adéla Novotná, Zora Nováková, Barbora Havlínová, Werner Tueckmantel, Helena Dráberová, Pavel Majer, Mike Schutkowski, Alan Kozikowski, Lubomír Rulíšek, Cyril Bařinka

Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines

基于脂肪酰化赖氨酸的连续荧光 Sirtuin 活性测定

Matthes Zessin, Marat Meleshin, Sebastian Hilscher, Cordelia Schiene-Fischer, Cyril Barinka, Manfred Jung, Mike Schutkowski

Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms

揭示 HDAC 同工酶的强效去乳酰酶和去丙酮酰酶活性

Matthes Zessin, Marat Meleshin, Lucas Praetorius, Wolfgang Sippl, Cyril Bařinka, Mike Schutkowski

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

具有抗白血病活性的新型 I 类选择性组蛋白去乙酰化酶 (HDAC) 抑制剂吡嗪连接的 2-氨基苯甲酰胺的合成、分子对接和生物学表征

Hany S Ibrahim, Mohamed Abdelsalam, Yanira Zeyn, Matthes Zessin, Al-Hassan M Mustafa, Marten A Fischer, Patrik Zeyen, Ping Sun, Emre F Bülbül, Anita Vecchio, Frank Erdmann, Matthias Schmidt, Dina Robaa, Cyril Barinka, Christophe Romier, Mike Schutkowski, Oliver H Krämer, Wolfgang Sippl

The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation

HDAC6 无序的 N 端是一个微管结合域,对于有效的微管蛋白去乙酰化至关重要

Kseniya Ustinova, Zora Novakova, Makoto Saito, Marat Meleshin, Jana Mikesova, Zsofia Kutil, Petra Baranova, Barbora Havlinova, Mike Schutkowski, Patrick Matthias, Cyril Barinka

The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries

使用乙酰基肽微阵列和肽库揭示组蛋白去乙酰化酶 6 结构域的底物特异性

Zsofia Kutil, Lubica Skultetyova, David Rauh, Marat Meleshin, Ivan Snajdr, Zora Novakova, Jana Mikesova, Jiri Pavlicek, Martin Hadzima, Petra Baranova, Barbora Havlinova, Pavel Majer, Mike Schutkowski, Cyril Barinka