日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse

对染色体碎裂型SHH髓母细胞瘤进行时空转录组学分析,鉴定出多个耐药基因克隆并导致复发

Ilia Kats # ,Milena Simovic-Lorenz # ,Hannah Sophia Schreiber # ,Pooja Sant ,Jan-Philipp Mallm ,Verena Körber ,Albert Li ,Pravin Velmurugan ,Sophie Heuer ,Luisa Kües ,Frauke Devens ,Martin Sill ,Manfred Jugold ,Mahmoud Moustafa ,Amir Abdollahi ,Frank Winkler ,Andrey Korshunov ,Stefan M Pfister ,Oliver Stegle ,Aurélie Ernst

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

染色体碎裂性髓母细胞瘤的多组学和单细胞分析揭示了基因组不稳定性的基因组和转录组后果

Petr Smirnov #, Moritz J Przybilla #, Milena Simovic-Lorenz #, R Gonzalo Parra #, Hana Susak #, Manasi Ratnaparkhe, John Kl Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R Ghasemi, Kendra Korinna Ma

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures

髓母细胞瘤诊断和治疗后长读长测序揭示了复杂的重排模式和表观遗传特征

Tobias Rausch ,Rene Snajder ,Adrien Leger ,Milena Simovic ,Mădălina Giurgiu ,Laura Villacorta ,Anton G Henssen ,Stefan Fröhling ,Oliver Stegle ,Ewan Birney ,Marc Jan Bonder ,Aurelie Ernst ,Jan O Korbel

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model

碳离子放射治疗可在原位 Li-Fraumeni 患者来源的小鼠模型中根除伴有染色体碎裂的髓母细胞瘤

Milena Simovic, Michiel Bolkestein, Mahmoud Moustafa, John K L Wong, Verena Körber, Sarah Benedetto, Umar Khalid, Hannah Sophia Schreiber, Manfred Jugold, Andrey Korshunov, Daniel Hübschmann, Norman Mack, Stephan Brons, Pei-Chi Wei, Michael O Breckwoldt, Sabine Heiland, Martin Bendszus, Jürgen Debus

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

DNA损伤修复缺陷导致小鼠和人类肿瘤中频繁发生灾难性的基因组事件

Manasi Ratnaparkhe, John K L Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T W Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M Downing, Stefan M Pfister,