日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp-overexpressing cancer models

QW-5-70靶向秋水仙碱结合位点,并在P-gp过表达的癌症模型中表现出抗肿瘤活性。

Xie, Yang; Hou, Ruida; Albadari, Najah; Chen, Hao; Miller, Darcie J; Quadrozzi Gruntz, Judith; Oldham, Michael L; Kamal, Mir Shahriar; Jiang, Jianxiong; Wu, Zhongzhi; Miller, Duane D; Li, Wei

Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors.

设计和合成新型 4-芳基-2-苯甲酰基咪唑类化合物作为秋水仙碱结合位点抑制剂

Albadari Najah, Xie Yang, Wang Qinghui, Miller Darcie J, Gruntz Judith Quadrozzi, Oldham Michael L, Chen Hao, Ma Dejian, Wu Zhongzhi, Miller Duane D, Li Wei

I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation

晶体衍射数据质量评估中 I/σI 与 {Rmerg, Rmeas, Rpim, CC1/2} 的关系

Fu, Zheng-Qing; Geisbrecht, Brian V; Bouyain, Samuel; Dyda, Fred; Chrzas, John; Kandavelu, Palani; Miller, Darcie J; Wang, Bi-Cheng

PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network.

PROTAC介导的核受体激活(而非降解)揭示了复杂的配体-受体相互作用网络

Huber Andrew D, Lin Wenwei, Poudel Shyaron, Miller Darcie J, Chen Taosheng

EMhub: a web platform for data management and on-the-fly processing in scientific facilities

EMhub:一个用于科学设施中数据管理和即时处理的网络平台

de la Rosa-Trevin, Jose M; Sharov, Grigory; Fleischmann, Stefan; Morado, Dustin; Bollinger, John C; Miller, Darcie J; Terry, Daniel S; Blanchard, Scott C; Fernandez, Israel S; Carroni, Marta

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

对APC/C泛素变体抑制剂进行蛋白质工程改造,发现了一个隐蔽的K48泛素链结合位点。

Watson, Edmond R; Grace, Christy R R; Zhang, Wei; Miller, Darcie J; Davidson, Iain F; Prabu, J Rajan; Yu, Shanshan; Bolhuis, Derek L; Kulko, Elizaveta T; Vollrath, Ronnald; Haselbach, David; Stark, Holger; Peters, Jan-Michael; Brown, Nicholas G; Sidhu, Sachdev S; Schulman, Brenda A

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

双环E3结构通过APC/C调控多泛素化和泛素链延伸。

Brown, Nicholas G; VanderLinden, Ryan; Watson, Edmond R; Weissmann, Florian; Ordureau, Alban; Wu, Kuen-Phon; Zhang, Wei; Yu, Shanshan; Mercredi, Peter Y; Harrison, Joseph S; Davidson, Iain F; Qiao, Renping; Lu, Ying; Dube, Prakash; Brunner, Michael R; Grace, Christy R R; Miller, Darcie J; Haselbach, David; Jarvis, Marc A; Yamaguchi, Masaya; Yanishevski, David; Petzold, Georg; Sidhu, Sachdev S; Kuhlman, Brian; Kirschner, Marc W; Harper, J Wade; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

HECT E3泛素连接酶介导的泛素连接和赖氨酸优先性机制

Kamadurai, Hari B; Qiu, Yu; Deng, Alan; Harrison, Joseph S; Macdonald, Chris; Actis, Marcelo; Rodrigues, Patrick; Miller, Darcie J; Souphron, Judith; Lewis, Steven M; Kurinov, Igor; Fujii, Naoaki; Hammel, Michal; Piper, Robert; Kuhlman, Brian; Schulman, Brenda A

Structural basis for the transcriptional regulation of membrane lipid homeostasis

膜脂稳态转录调控的结构基础

Miller, Darcie J; Zhang, Yong-Mei; Subramanian, Chitra; Rock, Charles O; White, Stephen W

How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.

泛素 E1 的细菌祖先 MccB 如何启动微生素 C7 抗生素的生物合成

Regni Catherine A, Roush Rebecca F, Miller Darcie J, Nourse Amanda, Walsh Christopher T, Schulman Brenda A