日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery, Optimization, and Evaluation of Non-Nucleoside SARS-CoV-2 NSP14 Inhibitors

非核苷类SARS-CoV-2 NSP14抑制剂的发现、优化和评价

Miller, Michael W; Meyer, Cindy; Garzia, Aitor; Hoffmann, Hans-Heinrich; Khan, Tanweer A; Egbertson, Melissa; Myers, Robert W; Liverton, Nigel; Kargman, Stacia; Davis, Jada A; Ganichkin, Oleg; Nitsche, Julius; Steinbacher, Stefan; Dagan, Shlomi; Glickman, J Fraser; Rice, Charles M; Tuschl, Thomas; Meinke, Peter T; Huggins, David J

Discovery of Novel Isofunctional SARS-CoV‑2 NSP14 RNA Cap Methyltransferase Inhibitors by Structure-Based Virtual Screening

通过基于结构的虚拟筛选发现新型同源SARS-CoV-2 NSP14 RNA帽甲基转移酶抑制剂

Meyer, Cindy; Michino, Mayako; Huggins, David J; Garzia, Aitor; Davis, Jada A; Miller, Michael W; Liverton, Nigel; Hoffmann, Hans-Heinrich; Glickman, J Fraser; Nitsche, Julius; Ganichkin, Oleg; Steinbacher, Stefan; Rice, Charles M; Meinke, Peter T; Tuschl, Thomas

Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer

天然朊病毒的冷冻电镜结构:鹿源慢性消耗性疾病原纤维

Alam, Parvez; Hoyt, Forrest; Artikis, Efrosini; Soukup, Jakub; Hughson, Andrew G; Schwartz, Cindi L; Barbian, Kent; Miller, Michael W; Race, Brent; Caughey, Byron

Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable In Vivo Studies: Discovery of TDI-11055

优化小分子ENL YEATS抑制剂以开展体内研究:TDI-11055的发现

Michino, Mayako; Khan, Tanweer A; Miller, Michael W; Fukase, Yoshiyuki; Vendome, Jeremie; Adura, Carolina; Glickman, J Fraser; Liu, Yiman; Wan, Liling; Allis, C David; Stamford, Andrew W; Meinke, Peter T; Renzetti, Louis M; Kargman, Stacia; Liverton, Nigel J; Huggins, David J

Monitoring of chronic wasting disease (CWD) (IV)

慢性消耗性疾病(CWD)监测(IV)

Koutsoumanis, Konstantinos; Allende, Ana; Alvarez-Ordoñez, Avelino; Bolton, Declan; Bover-Cid, Sara; Chemaly, Marianne; Davies, Robert; De Cesare, Alessandra; Herman, Lieve; Hilbert, Friederike; Lindqvist, Roland; Nauta, Maarten; Peixe, Luisa; Skandamis, Panagiotis; Suffredini, Elisabetta; Miller, Michael W; Mysterud, Atle; Nöremark, Maria; Simmons, Marion; Tranulis, Michael A; Vaccari, Gabriele; Viljugrein, Hildegunn; Ortiz-Pelaez, Angel; Ru, Giuseppe

Apparent stability masks underlying change in a mule deer herd with unmanaged chronic wasting disease

表面上的稳定掩盖了患有未经控制的慢性消耗性疾病的骡鹿群的潜在变化。

Fisher, Mark C; Prioreschi, Ryan A; Wolfe, Lisa L; Runge, Jonathan P; Griffin, Karen A; Swanson, Heather M; Miller, Michael W

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

在表达麋鹿或鹿朊病毒蛋白的小鼠体内,新型挪威朊病毒株的传播过程中,会发生与已建立的北美慢性消耗性疾病(CWD)相对应的朊病毒株构象的适应性选择。

Bian, Jifeng; Kim, Sehun; Kane, Sarah J; Crowell, Jenna; Sun, Julianna L; Christiansen, Jeffrey; Saijo, Eri; Moreno, Julie A; DiLisio, James; Burnett, Emily; Pritzkow, Sandra; Gorski, Damian; Soto, Claudio; Kreeger, Terry J; Balachandran, Aru; Mitchell, Gordon; Miller, Michael W; Nonno, Romolo; Vikøren, Turid; Våge, Jørn; Madslien, Knut; Tran, Linh; Vuong, Tram Thu; Benestad, Sylvie L; Telling, Glenn C

Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear

利用RT-QuIC分析外耳组织检测骡鹿和白尾鹿的慢性消耗性疾病

Ferreira, Natalia C; Charco, Jorge M; Plagenz, Jakob; Orru, Christina D; Denkers, Nathanial D; Metrick, Michael A 2nd; Hughson, Andrew G; Griffin, Karen A; Race, Brent; Hoover, Edward A; Castilla, Joaquín; Nichols, Tracy A; Miller, Michael W; Caughey, Byron

Reduction of Chronic Wasting Disease Prion Seeding Activity following Digestion by Mountain Lions

山狮消化后慢性消耗性疾病朊病毒播散活性降低

Baune, Chase; Wolfe, Lisa L; Schott, Kristen C; Griffin, Karen A; Hughson, Andrew G; Miller, Michael W; Race, Brent

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

通过霍夫迈斯特离子比对,蛋白质病种子扩增检测在生物样本中的灵敏度提高了百万倍

Metrick, Michael A 2nd; do Carmo Ferreira, Natalia; Saijo, Eri; Hughson, Andrew G; Kraus, Allison; Orrú, Christina; Miller, Michael W; Zanusso, Gianluigi; Ghetti, Bernardino; Vendruscolo, Michele; Caughey, Byron