日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

利用实验室进化的 CRISPR 相关转座酶在人类细胞中实现可编程基因插入

Witte, Isaac P; Lampe, George D; Eitzinger, Simon; Miller, Shannon M; Berríos, Kiara N; McElroy, Amber N; King, Rebeca T; Stringham, Olivia G; Gelsinger, Diego R; Vo, Phuc Leo H; Chen, Albert T; Tolar, Jakub; Osborn, Mark J; Sternberg, Samuel H; Liu, David R

Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists.

对芳基海藻糖Mincle激动剂的区域化学和脂化进行系统评价

Riel Asia Marie S, Rungelrath Viktoria, Elwaie Tamer A, Rasheed Omer K, Hicks Linda, Ettenger George, You Dai-Chi, Smith Mira, Buhl Cassandra, Abdelwahab Walid, Miller Shannon M, Smith Alyson J, Burkhart David, Evans Jay T, Ryter Kendal T

Adjuvanted Vaccine Induces Functional Antibodies against Pseudomonas aeruginosa Filamentous Bacteriophages

佐剂疫苗可诱导产生针对铜绿假单胞菌丝状噬菌体的功能性抗体

Román-Cruz, Valery C; Miller, Shannon M; Schoener, Roman A; Lukasiewicz, Chase; Schmidt, Amelia K; DeBuysscher, Blair L; Burkhart, David; Secor, Patrick R; Evans, Jay T

Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis.

芳基海藻糖衍生物作为结核分枝杆菌疫苗佐剂

Ryter Kendal T, Ettenger George, Rasheed Omer K, Buhl Cassandra, Child Robert, Miller Shannon M, Holley David, Smith Alyson J, Evans Jay T

Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

新型脂化咪唑喹啉TLR7/8佐剂可诱导流感特异性Th1免疫反应,并保护小鼠免受异源H3N2流感病毒攻击

Miller, Shannon M; Cybulski, Van; Whitacre, Margaret; Bess, Laura S; Livesay, Mark T; Walsh, Lois; Burkhart, David; Bazin, Hélène G; Evans, Jay T

6,6'-Aryl trehalose analogs as potential Mincle ligands

6,6'-芳基海藻糖类似物作为潜在的Mincle配体

Rasheed, Omer K; Ettenger, George; Buhl, Cassandra; Child, Robert; Miller, Shannon M; Evans, Jay T; Ryter, Kendal T

Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity

优化具有 Toll 样受体 7 和 8 活性的 8-氧代腺嘌呤。

Bazin, Hélène G; Bess, Laura S; Livesay, Mark T; Li, Yufeng; Cybulski, Van; Miller, Shannon M; Johnson, David A; Evans, Jay T

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

循环排列和PAM修饰的Cas9变体扩大了碱基编辑器的靶向范围。

Huang, Tony P; Zhao, Kevin T; Miller, Shannon M; Gaudelli, Nicole M; Oakes, Benjamin L; Fellmann, Christof; Savage, David F; Liu, David R

Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity.

将合成的脂化 TLR4 和 TLR7/8 激动剂共同封装在脂质体双层中,可快速协同增强疫苗介导的体液免疫

Short Kristopher K, Miller Shannon M, Walsh Lois, Cybulski Van, Bazin Hélène, Evans Jay T, Burkhart David

Targeting fidelity of adenine and cytosine base editors in mouse embryos

小鼠胚胎中腺嘌呤和胞嘧啶碱基编辑器的靶向保真度

Lee, Hye Kyung; Willi, Michaela; Miller, Shannon M; Kim, Sojung; Liu, Chengyu; Liu, David R; Hennighausen, Lothar