Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
发现和基于结构的强效选择性 WD 重复结构域 5 (WDR5) 抑制剂，该抑制剂含有二氢异喹啉酮双环核心
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.9b01608
Tian Jianhua, Teuscher Kevin B, Aho Erin R, Alvarado Joseph R, Mills Jonathan J, Meyers Kenneth M, Gogliotti Rocco D, Han Changho, Macdonald Jonathan D, Sai Jiqing, Shaw J Grace, Sensintaffar John L, Zhao Bin, Rietz Tyson A, Thomas Lance R, Payne William G, Moore William J, Stott Gordon M, Kondo Jumpei, Inoue Masahiro, Coffey Robert J, Tansey William P, Stauffer Shaun R, Lee Taekyu, Fesik Stephen W
