日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia

现成的双重CAR-iNKT细胞免疫疗法可根除髓质和软脑膜高危KMT2A重排白血病

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2025029302
Ren, Hongwei; Elliott, Natalina; Lye, Bryan; Sharif Shohan, Mohammad Umer; Cross, Joe W; Field, Lucy; Ponnusamy, Kanagaraju; Rice, Siobhan; Jackson, Thomas; Leontari, Ilia; El Ouazzani, Nouhad; Thomas, Rebecca; Inglott, Sarah; Bartram, Jack; Smith, Owen; Bond, Jonathan; Roberts, Irene A G; Halsey, Christina; Bashford-Rogers, Rachael; Milne, Thomas A; Roy, Anindita; Karadimitris, Anastasios
T细胞
神经科学
白血病
T细胞
细胞生物学
KMT2A
免疫/内分泌
发表日期：2026
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Correction to "DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement"

对“DNA可编程蛋白质降解：通过DNA杂交和链置换动态控制蛋白水解靶向嵌合体活性”一文的更正

期刊:JACS Au
影响因子:8.7
doi:10.1021/jacsau.5c01700
Kashyap, Disha; Haider, Shozeb; Milne, Thomas A; Booth, Michael J
发表日期：2026
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Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.

以碱基对分辨率绘制染色质结构图，揭示了顺式调控元件相互作用的统一模型。

期刊:Cell
影响因子:42.5
doi:10.1016/j.cell.2025.10.013
Li Hangpeng, Dalgleish James L T, Lister George, Maristany Maria Julia, Huertas Jan, Dopico-Fernandez Ana M, Hamley Joseph C, Denny Nicholas, Bloye Gianna, Zhang Weijiao, Hentges Lance, Doll Roman, Wei Ye, Maresca Michela, Dimitrova Emilia, Pytowski Lior, Tunnacliffe Edward A J, Kassouf Mira, Higgs Doug, de Wit Elzo, Klose Robert J, Schermelleh Lothar, Collepardo-Guevara Rosana, Milne Thomas A, Davies James O J
信号转导
发表日期：2025
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Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients

急性淋巴细胞白血病中增强子异质性驱动患者差异基因表达

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2024028019
Smith, Alastair L; Denny, Nicholas; Chahrour, Catherine; Sharp, Kim; Arachi, Marta; Dopico-Fernandez, Ana M; Elliott, Natalina; Harman, Joe R; Jackson, Thomas; Geng, Huimin; Smith, Owen; Bond, Jonathan; Roberts, Irene; Stam, Ronald W; Crump, Nicholas T; Davies, James O J; Roy, Anindita; Milne, Thomas A
白血病
细胞生物学
发表日期：2025
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Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides

利用BET溴结构域辅助核输入实现反义寡核苷酸的靶向亚细胞定位和增强疗效

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c09544
Kashyap, Disha; Cadeddu, Martina; Oliver, Peter L; Milne, Thomas A; Booth, Michael J
细胞生物学
发表日期：2025
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DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition

DYRK1A抑制导致MYC和ERK激活，使KMT2A-R急性淋巴细胞白血病细胞对BCL2抑制敏感。

期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-025-02575-w
Ayyadevara, V S S Abhinav; Wertheim, Gerald; Gaur, Shikha; Chukinas, John A; Loftus, Joseph P; Lee, Sung June; Kumar, Anil; Swaminathan, Srividya; Bhansali, Rahul S; Childers, Wayne; Geng, Huimin; Milne, Thomas A; Hua, Xianxin; Bernt, Kathrin M; Besson, Thierry; Shi, Junwei; Crispino, John D; Carroll, Martin; Tasian, Sarah K; Hurtz, Christian
DYR
KMT2A
MAPK/ERK
白血病
BCL2
细胞生物学
MYC
DYRK1A
发表日期：2025
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DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement

DNA可编程蛋白质降解：通过DNA杂交和链置换动态控制蛋白水解靶向嵌合体活性

期刊:JACS Au
影响因子:8.7
doi:10.1021/jacsau.5c00422
Kashyap, Disha; Haider, Shozeb; Milne, Thomas A; Booth, Michael J
发表日期：2025
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Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking

通过溶酶体运输改造反义寡核苷酸，以实现靶向mRNA降解。

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d5sc03751d
Kashyap, Disha; Milne, Thomas A; Booth, Michael J
发表日期：2025
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PROM1/CD133 marks a proliferative stem cell-like population of blasts in KMT2A rearranged infant ALL

PROM1/CD133 标记 KMT2A 重排婴儿急性淋巴细胞白血病中增殖性干细胞样原始细胞群。

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2024015185
Cross, Joe Wilson; Field, Lucy; Smith, Alastair; Neil, Emily; Hamer, Lucy; Jackson, Thomas; Elliott, Natalina; Rice, Siobhan; Crump, Nicholas; Harman, Joe; Ling, Rebecca E; Wu, Qingqing; El Ouazzani, Nouhad; Thomas, Rebecca; Inglott, Sarah; Bartram, Jack; Smith, Owen; Bond, Jonathan; Roberts, Irene; Milne, Thomas A; Roy, Anindita
发育与干细胞
KMT2A
白血病
PROM1
CD133
干细胞
细胞生物学
CD13
发表日期：2025
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Active regulatory elements recruit cohesin to establish cell specific chromatin domains.

活性调控元件募集黏连蛋白以建立细胞特异性染色质结构域

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-96248-4
Georgiades Emily, Harrold Caroline, Roberts Nigel, Kassouf Mira, Riva Simone G, Sanders Edward, Downes Damien, Francis Helena S, Blayney Joseph, Oudelaar A Marieke, Milne Thomas A, Higgs Douglas, Hughes Jim R
细胞生物学
发表日期：2025
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