日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation

对药物诱发和自发性心脏复律的分析表明,两者终止心房颤动的模式相似。

van Hunnik, Arne; Sobota, Vladimír; Zeemering, Stef; Opacic, Dragan; Scaf, Billy; D'Alessandro, Elisa; Oyaert, Karel; Kuiper, Marion; Diness, Jonas G; Sørensen, Ulrik S; Milnes, James T; van der Heyden, Marcel A G; Jespersen, Thomas; Schotten, Ulrich; Verheule, Sander

Pharmacological inhibition of acetylcholine-regulated potassium current (I (K,ACh)) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events

在反复阻塞性呼吸事件的大鼠模型中,通过药物抑制乙酰胆碱调节的钾电流(I(K,ACh))可预防心房心律失常的改变。

Linz, Benedikt; Thostrup, Anne Hauge; Saljic, Arnela; Rombouts, Karlijn; Hertel, Julie Norup; Hohl, Mathias; Milnes, James; Tfelt-Hansen, Jacob; Linz, Dominik; Jespersen, Thomas

A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels

具有抗心律失常活性的苯并吡喃类化合物是含Kir3.1钾通道的抑制剂。

Cui, Meng; Alhamshari, Yaser; Cantwell, Lucas; Ei-Haou, Said; Eptaminitaki, Giasemi C; Chang, Mengmeng; Abou-Assali, Obada; Tan, Haozhou; Xu, Keman; Masotti, Meghan; Plant, Leigh D; Thakur, Ganesh A; Noujaim, Sami F; Milnes, James; Logothetis, Diomedes E

Effect of selective I(K,ACh) inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation

XAF-1407选择性抑制I(K,ACh)对马快速起搏诱发持续性房颤的影响

Fenner, Merle Friederike; Carstensen, Helena; Dalgas Nissen, Sarah; Melis Hesselkilde, Eva; Scott Lunddahl, Christine; Adler Hess Jensen, Maja; Loft-Andersen, Ameli Victoria; Sattler, Stefan Michael; Platonov, Pyotr; El-Haou, Said; Jackson, Claire; Tang, Raymond; Kirby, Robert; Ford, John; Schotten, Ulrich; Milnes, James; Svane Sørensen, Ulrik; Jespersen, Thomas; Buhl, Rikke

The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

乙酰胆碱激活钾电流抑制剂 XAF-1407 可终止山羊的持续性心房颤动

Sobota, Vladimír; Gatta, Giulia; van Hunnik, Arne; van Tuijn, Iris; Kuiper, Marion; Milnes, James; Jespersen, Thomas; Schotten, Ulrich; Verheule, Sander

Inhibition of voltage-gated Na(+) currents by eleclazine in rat atrial and ventricular myocytes

依来克嗪对大鼠心房和心室肌细胞中电压门控Na(+)电流的抑制作用

Caves, Rachel E; Carpenter, Alexander; Choisy, Stéphanie C; Clennell, Ben; Cheng, Hongwei; McNiff, Cameron; Mann, Brendan; Milnes, James T; Hancox, Jules C; James, Andrew F

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I(K,ACh)).

GNB5 的基因变异通过增加乙酰胆碱激活的钾电流 (I(K,ACh)) 来增强胆碱能反应,从而导致心动过缓

Veerman Christiaan C, Mengarelli Isabella, Koopman Charlotte D, Wilders Ronald, van Amersfoorth Shirley C, Bakker Diane, Wolswinkel Rianne, Hababa Mariam, de Boer Teun P, Guan Kaomei, Milnes James, Lodder Elisabeth M, Bakkers Jeroen, Verkerk Arie O, Bezzina Connie R

Wide-field time-correlated single photon counting-based fluorescence lifetime imaging microscopy

基于时间相关单光子计数的宽场荧光寿命成像显微镜

Suhling, Klaus; Hirvonen, Liisa M; Becker, Wolfgang; Smietana, Stefan; Netz, Holger; Milnes, James; Conneely, Thomas; Marois, Alix Le; Jagutzki, Ottmar; Festy, Fred; Petrášek, Zdeněk; Beeby, Andrew

The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation

IKur抑制剂XEN-D0103的正向频率依赖性电生理效应有利于房颤的治疗。

Ford, John; Milnes, James; El Haou, Said; Wettwer, Erich; Loose, Simone; Matschke, Klaus; Tyl, Benoit; Round, Patrick; Ravens, Ursula

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

源自人类多能干细胞的心房样心肌细胞是评估心房选择性药理学的可靠临床前模型。

Devalla, Harsha D; Schwach, Verena; Ford, John W; Milnes, James T; El-Haou, Said; Jackson, Claire; Gkatzis, Konstantinos; Elliott, David A; Chuva de Sousa Lopes, Susana M; Mummery, Christine L; Verkerk, Arie O; Passier, Robert