日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

FOXP3的表达依赖于细胞类型特异性的顺式调控元件和转录因子回路。

Jennifer M Umhoefer,Maya M Arce,Sivakanthan Kasinathan,Sean Whalen,Rama Dajani,Sanjana Subramanya,Laine Goudy,Julia A Belk,Royce Zhou,Minh T N Pham,Wenxi Zhang,Rosmely Hernandez,Carinna Tran,Nikhita Kirthivasan,Jacob W Freimer,Cody T Mowery,Vinh Nguyen,Mineto Ota,Benjamin G Gowen,Dimitre R Simeonov,Gemma L Curie,Zhongmei Li,Andy Y Chen,Jacob E Corn,Howard Y Chang,Qizhi Tang,Luke A Gilbert,Ansuman T Satpathy,Katherine S Pollard,Alexander Marson

Central control of dynamic gene circuits governs T cell rest and activation

动态基因回路的中央调控控制着T细胞的静息和激活。

Maya M Arce ,Jennifer M Umhoefer ,Nadia Arang ,Sivakanthan Kasinathan ,Jacob W Freimer ,Zachary Steinhart ,Haolin Shen ,Minh T N Pham ,Mineto Ota ,Anika Wadhera ,Rama Dajani ,Dmytro Dorovskyi ,Yan Yi Chen ,Qi Liu ,Yuan Zhou ,Danielle L Swaney ,Kirsten Obernier ,Brian R Shy ,Julia Carnevale ,Ansuman T Satpathy ,Nevan J Krogan ,Jonathan K Pritchard ,Alexander Marson

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

FOXP3的表达依赖于细胞类型特异性的顺式调控元件和转录因子回路。

Jennifer M Umhoefer ,Maya M Arce ,Sivakanthan Kasinathan ,Sean Whalen ,Rama Dajani ,Sanjana Subramanya ,Laine Goudy ,Julia A Belk ,Royce Zhou ,Minh T N Pham ,Wenxi Zhang ,Rosmely Hernandez ,Carinna Tran ,Nikhita Kirthivasan ,Jacob W Freimer ,Cody T Mowery ,Vinh Nguyen ,Mineto Ota ,Benjamin G Gowen ,Dimitre R Simeonov ,Gemma L Curie ,Zhongmei Li ,Andy Y Chen ,Jacob E Corn ,Howard Y Chang ,Qizhi Tang ,Luke A Gilbert ,Ansuman T Satpathy ,Katherine S Pollard ,Alexander Marson

Base-editing mutagenesis maps alleles to tune human T cell functions

碱基编辑诱变技术通过绘制等位基因图谱来调节人类T细胞功能

Ralf Schmidt #,Carl C Ward #,Rama Dajani,Zev Armour-Garb,Mineto Ota,Vincent Allain,Rosmely Hernandez,Madeline Layeghi,Galen Xing,Laine Goudy,Dmytro Dorovskyi,Charlotte Wang,Yan Yi Chen,Chun Jimmie Ye,Brian R Shy,Luke A Gilbert,Justin Eyquem,Jonathan K Pritchard,Stacie E Dodgson,Alexander Marson

An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction

自身免疫转录回路驱动FOXP3+调节性T细胞功能障碍

Tomokazu S Sumida ,Matthew R Lincoln ,Liang He ,Yongjin Park ,Mineto Ota ,Akiko Oguchi ,Raku Son ,Alice Yi ,Helen A Stillwell ,Greta A Leissa ,Keishi Fujio ,Yasuhiro Murakawa ,Alexander M Kulminski ,Charles B Epstein ,Bradley E Bernstein ,Manolis Kellis ,David A Hafler

Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease

通过对原代 CD4+ T 细胞中 CRISPR 干扰的基因调控网络推断,阐明了免疫疾病的基因组基础

Joshua S Weinstock, Maya M Arce, Jacob W Freimer, Mineto Ota, Alexander Marson, Alexis Battle, Jonathan K Pritchard

Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis

Janus 激酶抑制剂的表观遗传靶点与类风湿关节炎的遗传风险有关

Haruka Tsuchiya #, Mineto Ota #, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo, Keishi Fujio

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

CRISPR筛选技术能够解码触发γδ T细胞检测的癌细胞通路。

Murad R Mamedov,Shane Vedova #,Jacob W Freimer #,Avinash Das Sahu,Amrita Ramesh,Maya M Arce,Angelo D Meringa,Mineto Ota,Peixin Amy Chen,Kristina Hanspers,Vinh Q Nguyen,Kirsten A Takeshima,Anne C Rios,Jonathan K Pritchard,Jürgen Kuball,Zsolt Sebestyen,Erin J Adams,Alexander Marson

Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease

通过对原代 CD4+ T 细胞中 CRISPR 干扰的基因调控网络推断,阐明了免疫疾病的基因组基础

Joshua S Weinstock, Maya M Arce, Jacob W Freimer, Mineto Ota, Alexander Marson, Alexis Battle, Jonathan K Pritchard

AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination

AFF3是自身免疫性疾病的易感因子,也是免疫球蛋白类别转换重组的分子促进因子。

Shin-Ichi Tsukumo ,Poorani Ganesh Subramani ,Noé Seija ,Mizuho Tabata ,Yoichi Maekawa ,Yuya Mori ,Chieko Ishifune ,Yasushi Itoh ,Mineto Ota ,Keishi Fujio ,Javier M Di Noia ,Koji Yasutomo