日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications

靶向代谢-表观遗传-免疫轴治疗癌症：分子机制及治疗意义

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-025-02334-4
Wang, Xing; Luo, Xiyuan; Xiao, Ruiling; Liu, Xiaohong; Zhou, Feihan; Jiang, Decheng; Bai, Jialu; Cui, Ming; You, Lei; Zhao, Yupei
肿瘤
表观遗传
肿瘤免疫
代谢
免疫/内分泌
发表日期：2026
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CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of TCE-secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity.

CD3É› 纳米抗体工程化细胞外囊泡驱动体内生成分泌 TCE 的 CAR-T 细胞，用于实体瘤治疗，具有记忆反应和最小免疫原性。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202519440
Huang Shi-Wei, Lin Yu-Chuan, Pan Chih-Ming, Chen Yeh, Shie Ming-You, Chen Cheng-Yu, Kan Kai-Wen, Chen Yi-Wen, Liu Ming-Chao, Wu Chung-Chun, Chiang Yu-Ting, Ho Huai-Ping, Lin Chen-Yu, Lin Pei-Ying, Huang Yu-Han, Rusli Steffany, Mao Wan-Yu, Huang Pei-Wen, Wang Sin-Ting, Tsai Wan-Chen, Chiu Ya-Hsu, Lin Ting-Hsun, Chiang Wan-Ling, Chang Che-Kai, Lai Zi-Lun, Chen Mei-Chih, Chiu Shao-Chih, Cho Der-Yang
细胞生物学
CD3
囊泡
发表日期：2026
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Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury

构建靶向整合素αvβ8的细胞外囊泡，以递送BDNF mRNA促进脊髓损伤后的运动功能恢复

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-026-04222-7
Shie, Ming-You; Chiu, Cheng-Di; Chen, Yeh; Lin, Yen-Hong; Yu, Min-Hua; Chiu, You-Pen; Chiu, Po-Fan; Chen, Cheng-Yu; Chen, Yi-Wen; Chen, Mei-Chih; Cho, Der-Yang
神经科学
脊髓损伤
BDNF
囊泡
细胞生物学
发表日期：2026
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Sulforaphane Synergizes With PD-1 Blockade Through Activating CD8(+) T Cells in Non-Small Cell Lung Cancer: Preclinical and Clinical Investigations

萝卜硫素通过激活非小细胞肺癌中的 CD8(+) T 细胞与 PD-1 阻断剂产生协同作用：临床前和临床研究

期刊:MedComm
影响因子:10.7
doi:10.1002/mco2.70688
Li, Jieyao; Liu, Jinyan; Wang, Zheng; Zhao, Ming; You, Mingming; Fu, Ziyi; Guo, Caijuan; Zhang, Tengyue; Liu, Shasha; Yue, Dongli; Yang, Shuangning; Li, Yixin; Gao, Qun; Liu, Yanfen; Huang, Jianmin; Wang, Liping; Zhang, Yi
肺癌
肿瘤
T细胞
肿瘤免疫
CD8
细胞生物学
PD-1
发表日期：2026
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Cross-sectional associations between physical activity and sarcopenia at different life stages: evidence from CHARLS

不同生命阶段体力活动与肌肉减少症的横断面关联：来自CHARLS的证据

期刊:BMC Geriatrics
影响因子:3.8
doi:10.1186/s12877-025-06938-x
Huang, Yongyu; Wang, Qing; Wang, Guangjie; Ding, Ming; You, Yanwei; Li, Fangbo; Wang, Taoran; Yan, Yongtao
发表日期：2026
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Unidirectional perfect absorption induced by chiral coupling in spin-momentum locked waveguide magnonics

自旋动量锁定波导磁子学中手性耦合诱导的单向完美吸收

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-63305-5
Qian, Jie; Hong, Qi; Wang, Zi-Yuan; Wu, Wen-Xin; Yang, Yihao; Hu, Can-Ming; You, Jian-Qiang; Wang, Yi-Pu
发表日期：2025
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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery.

构建靶向 HLA-G 的细胞外囊泡纳米平台，通过精准的癌症药物递送增强癌症治疗效果。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66451-y
Shie Ming-You, Huang Shi-Wei, Chen Yeh, Chen Mei-Chih, Pan Chih-Ming, Chen Cheng-Yu, Lin Yen-Hong, Yu Min-Hua, Kan Kai-Wen, Chiu Shao-Chih, Ho Hui-Chun, Chen Yi-Wen, Cho Der-Yang
细胞生物学
囊泡
发表日期：2025
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Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson's disease therapy

利用工程化细胞外囊泡介导的姜黄素递送系统，在大脑微环境中调节溶酶体、线粒体和小胶质细胞的重编程，从而治疗帕金森病。

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03911-z
Shie, Ming-You; Chen, Mei-Chih; Chen, Yeh; Huang, Shi-Wei; Lin, Yen-Hong; Yu, Min-Hua; Pan, Chih-Ming; Chen, Cheng-Yu; Chen, Yi-Wen; Hsieh, Ching-Liang; Chiu, Shao-Chih; Kao, Shung-Te; Lin, Jaung-Geng; Cho, Der-Yang
胶质细胞
帕金森
神经科学
线粒体
囊泡
细胞生物学
发表日期：2025
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Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration

锂掺杂硅酸钙支架激活M2极化巨噬细胞来源的富含miR-145-5p的细胞外囊泡，从而增强骨免疫调节，加速骨再生

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03679-2
Kuo, Ting-You; Lin, Tsung-Li; Lin, Yen-Hong; Chen, Cheng-Yu; Cho, Der-Yang; Chen, Yi-Wen; Shie, Ming-You
巨噬细胞
细胞生物学
囊泡
巨噬细胞
免疫/内分泌
发表日期：2025
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Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing

胶原水凝胶包裹源自硅酸钙刺激的脂肪间充质干细胞的细胞外囊泡对糖尿病治疗的免疫调节作用

期刊:Journal of Nanobiotechnology
影响因子:10.6
doi:10.1186/s12951-025-03097-4
Yen-Hong Lin #, Yeh Chen #, En-Wei Liu #, Mei-Chih Chen, Min-Hua Yu, Cheng-Yu Chen, Chia-Che Ho, Tai-Yi Hsu-Jiang, Jian-Jr Lee, Der-Yang Cho, Ming-You Shie8
免疫
糖尿病
干细胞
发表日期：2025
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