日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies

核苷酸插入和缺失补充点突变,大大扩大了抗体体细胞超突变产生的多样性

Peter M Bowers, Petra Verdino, Zhengyuan Wang, Jean da Silva Correia, Mark Chhoa, Griffin Macondray, Minjee Do, Tamlyn Y Neben, Robert A Horlick, Robyn L Stanfield, Ian A Wilson, David J King

High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation

无需制备杂交瘤即可获得高亲和力人源化抗体;免疫与哺乳动物细胞展示和体外体细胞超突变相结合

Audrey D McConnell, Minjee Do, Tamlyn Y Neben, Vladimir Spasojevic, Josh MacLaren, Andy P Chen, Laurence Altobell 3rd, John L Macomber, Ashley D Berkebile, Robert A Horlick, Peter M Bowers, David J King