日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease

利用同源hiPSC衍生的VSMC构建的3D芯片血管模型揭示了NOTCH3驱动的脑小血管疾病改变

期刊:Stem Cell Reports
影响因子:5.1
doi:10.1016/j.stemcr.2026.102863
Vila Cuenca, Marc; Tsikari, Theano; Cerfontaine, Minne N; Gallant, James L; van den Hil, Francijna E; Bouma, Marga J; Dijkstra, Kyra L; Gravesteijn, Gido; de Vries, Antoine A F; Mummery, Christine L; Rutten, Julie W; Lesnik Oberstein, Saskia A J; Orlova, Valeria V
NOTCH
3D/类器官
OTC
神经科学
发表日期：2026
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Expanding the Clinicoradiologic Phenotype of the CTSA-Associated Small Vessel Disease CARASAL: A Comparison With CADASIL

扩展CTSA相关小血管疾病CARASAL的临床放射学表型：与CADASIL的比较

期刊:Neurology-Genetics
影响因子:3.7
doi:10.1212/NXG.0000000000200358
Cerfontaine, Minne N; Gravesteijn, Gido; Hack, Remco J; Gesierich, Benno; Kruit, Mark C; Van Den Wijngaard, Ido R; Notting, Irene C; Nibbeling, Esther A R; Bugiani, Marianna; van der Knaap, Marjo S; Boon, Camiel J F; Duering, Marco; Rutten, Julie W; Lesnik Oberstein, Saskia A J
RAS
ADAS
ADA
发表日期：2026
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Small Vessel Disease Phenotype Associated With Monoallelic NOTCH3 Loss-of-Function Variants

与单等位基因 NOTCH3 功能丧失变异相关的小血管疾病表型

期刊:Neurology
影响因子:8.5
doi:10.1212/WNL.0000000000214021
van Asbeck, Josephine S; Gravesteijn, Gido; Cerfontaine, Minne N; Vreijling, Jeroen P; Mulder, Aat A; Koning, Roman I; Kruit, Mark C; Bersano, Anna; Muir, Keith W; Neilson, Sam J; Meschia, James F; Shourav, Md Manjurul Islam; Koupparis, Andreas; Lee, Yi-Chung; Rifino, Nicola; Hack, Remco J; Nibbeling, Esther A R; Lesnik Oberstein, Saskia A J; Rutten, Julie W
OTC
NOTCH
发表日期：2025
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Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort - Implications for NOTCH3 Variant-Specific Disease Prediction

CADASIL队列中血管NOTCH3聚集与疾病严重程度的关联——对NOTCH3变异体特异性疾病预测的意义

期刊:Annals of Neurology
影响因子:7.7
doi:10.1002/ana.27240
Cerfontaine, Minne N; Gravesteijn, Gido; Hack, Remco J; Dijkstra, Kyra L; Rodríguez-Girondo, Mar; Gesierich, Benno; Witjes-Ané, Marie-Noëlle W; van Doorn, Remco; Duering, Marco; Rutten, Julie W; Lesnik Oberstein, Saskia A J
ADAS
OTC
NOTCH
ADA
发表日期：2025
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Technical and clinical validation of a novel deep learning-based white matter hyperintensity segmentation tool

一种新型基于深度学习的白质高信号分割工具的技术和临床验证

期刊:Cerebral Circulation Cognition and Behavior
影响因子:2.8
doi:10.1016/j.cccb.2025.100393
Gesierich, Benno; Pirpamer, Lukas; Meier, Dominik S; Amann, Michael; Cerfontaine, Minne N; de Leeuw, Frank-Erik; Maillard, Pauline; Moy, Sue; Helmer, Karl G; Kühne, Michael; Bonati, Leo H; Rutten, Julie W; Lesnik Oberstein, Saskia A J; Duering, Marco
信号转导
发表日期：2025
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Association of NOTCH3 Variant Risk Category With 2-Year Clinical and Radiologic Small Vessel Disease Progression in Patients With CADASIL

NOTCH3 变异风险类别与 CADASIL 患者 2 年临床和放射学小血管疾病进展的相关性

期刊:Neurology
影响因子:8.5
doi:10.1212/WNL.0000000000209310
Cerfontaine, Minne N; Hack, Remco J; Gesierich, Benno; Duering, Marco; Witjes-Ané, Marie-Noëlle W; Rodríguez-Girondo, Mar; Gravesteijn, Gido; Rutten, Julie; Lesnik Oberstein, Saskia A J
ADAS
OTC
NOTCH
ADA
发表日期：2024
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Three-tiered EGFr domain risk stratification for individualized NOTCH3-small vessel disease prediction

基于三级 EGFR 结构域风险分层的个体化 NOTCH3 小血管疾病预测

期刊:Brain
影响因子:11.7
doi:10.1093/brain/awac486
Hack, Remco J; Gravesteijn, Gido; Cerfontaine, Minne N; Santcroos, Mark A; Gatti, Laura; Kopczak, Anna; Bersano, Anna; Duering, Marco; Rutten, Julie W; Lesnik Oberstein, Saskia A J
EGFR
EGF
OTC
NOTCH
发表日期：2023
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Effect of NOTCH3 EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes

NOTCH3 EGFR 组、性别和心血管危险因素对 CADASIL 临床和神经影像学结果的影响

期刊:Stroke
影响因子:8.9
doi:10.1161/STROKEAHA.122.039325
Hack, Remco J; Cerfontaine, Minne N; Gravesteijn, Gido; Tap, Stephan; Hafkemeijer, Anne; van der Grond, Jeroen; Witjes-Ané, Marie-Noëlle; Baas, Frank; Rutten, Julie W; Lesnik Oberstein, Saskia A J
ADAS
OTC
NOTCH
EGF
EGFR
ADA
发表日期：2022
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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonance Imaging and Skin Biopsy Beyond Age 50 Years

携带致病性 NOTCH3 变异的家族成员，即使到了 50 岁以后，脑部磁共振成像和皮肤活检结果也可能正常，但其患有伴皮质下梗死和脑白质病变的常染色体显性遗传性脑动脉病。

期刊:Stroke
影响因子:8.9
doi:10.1161/STROKEAHA.121.036307
Hack, Remco J; Gravesteijn, Gido; Cerfontaine, Minne N; Hegeman, Ingrid M; Mulder, Aat A; Lesnik Oberstein, Saskia A J; Rutten, Julie W
NOTCH
OTC
神经科学
发表日期：2022
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NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature

NOTCH3变异位点与CADASIL血管中的NOTCH3聚集负荷相关

期刊:Neuropathology and Applied Neurobiology
影响因子:3.4
doi:10.1111/nan.12751
Gravesteijn, Gido; Hack, Remco J; Mulder, Aat A; Cerfontaine, Minne N; van Doorn, Remco; Hegeman, Ingrid M; Jost, Carolina R; Rutten, Julie W; Lesnik Oberstein, Saskia A J
ADAS
OTC
NOTCH
ADA
发表日期：2022
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