Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction

Nrf2 缺乏导致视网膜色素上皮细胞中受损的 IDH 穿梭和戊糖磷酸途径产生的 NADPH 减少，从而加剧氧化应激引起的线粒体功能障碍