日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation.

Sirtuin-1 直接结合并使肝脏 PCSK9 去乙酰化，从而促进抑制 LDL 受体降解

期刊:Cardiovascular Research
影响因子:13.3
doi:10.1093/cvr/cvaf087
Velagapudi Srividya, Miranda Melroy X, Adla Priyanka, Kraler Simon, Mohammed Shafeeq A, Baki Shekhar, Robert Jerome, Rohrer Lucia, Lee Hwan, Jang Hyun-Duk, Obeid Slayman, Tailleux Anne, Staels Bart, Sepuri Naresh Babu V, Paneni Francesco, Gutti Ravi Kumar, von Eckardstein Arnold, Kim Hyo-Soo, Akhmedov Alexander, Camici Giovanni G, Lüscher Thomas F
信号转导
乙酰化
发表日期：2025
文献求助 收藏

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Sirt1激活剂SRT3025通过减少肝脏Pcsk9分泌和增强Ldlr表达，在Apoe-/-小鼠中发挥抗动脉粥样硬化作用。

期刊:European Heart Journal
影响因子:35.6
doi:10.1093/eurheartj/ehu095
Miranda, Melroy X; van Tits, Lambertus J; Lohmann, Christine; Arsiwala, Tasneem; Winnik, Stephan; Tailleux, Anne; Stein, Sokrates; Gomes, Ana P; Suri, Vipin; Ellis, James L; Lutz, Thomas A; Hottiger, Michael O; Sinclair, David A; Auwerx, Johan; Schoonjans, Kristina; Staels, Bart; Lüscher, Thomas F; Matter, Christian M
心血管
动脉粥样硬化
发表日期：2015
文献求助 收藏

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Sirt3基因缺失不影响动脉粥样硬化，但会加速LDL受体敲除小鼠的体重增加并损害其快速代谢适应能力：对心血管危险因素发展的影响

期刊:Basic Research in Cardiology
影响因子:8
doi:10.1007/s00395-013-0399-0
Winnik, Stephan; Gaul, Daniel S; Preitner, Frédéric; Lohmann, Christine; Weber, Julien; Miranda, Melroy X; Liu, Yilei; van Tits, Lambertus J; Mateos, José María; Brokopp, Chad E; Auwerx, Johan; Thorens, Bernard; Lüscher, Thomas F; Matter, Christian M
信号转导
心血管
动脉粥样硬化
代谢
发表日期：2014
文献求助 收藏

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

FIH羟化酶是一种细胞过氧化物传感器，可调节HIF转录活性。

期刊:EMBO Reports
影响因子:6.2
doi:10.1038/embor.2012.9
Masson, Norma; Singleton, Rachelle S; Sekirnik, Rok; Trudgian, David C; Ambrose, Lucy J; Miranda, Melroy X; Tian, Ya-Min; Kessler, Benedikt M; Schofield, Christopher J; Ratcliffe, Peter J
细胞生物学
FIH
发表日期：2012
文献求助 收藏