PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation
PIK3CA突变能够通过mTOR介导的MCL-1翻译靶向治疗乳腺肿瘤依赖性。
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.aae0348
Anderson, Gray R; Wardell, Suzanne E; Cakir, Merve; Crawford, Lorin; Leeds, Jim C; Nussbaum, Daniel P; Shankar, Pallavi S; Soderquist, Ryan S; Stein, Elizabeth M; Tingley, Jennifer P; Winter, Peter S; Zieser-Misenheimer, Elizabeth K; Alley, Holly M; Yllanes, Alexander; Haney, Victoria; Blackwell, Kimberly L; McCall, Shannon J; McDonnell, Donald P; Wood, Kris C