日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

RNA偶联CRISPR筛选揭示ZNF207是早衰症中LMNA异常剪接的调节因子

Amit K Behera,Jeongjin J Kim,Shreya Kordale,Filip Pekovic,Arun Prasath Damodaran,Bandana Kumari,Sandra Vidak,Ethan Dickson,Mei-Sheng Xiao,Gerard Duncan,Thorkell Andresson,Tom Misteli,Eugene Valkov,Thomas Gonatopoulos-Pournatzis

Orderly mitosis shapes interphase genome architecture

有序的有丝分裂塑造了间期基因组结构

Guin, Krishnendu; Keikhosravi, Adib; Chari, Raj; Pegoraro, Gianluca; Misteli, Tom

TAD boundaries and gene activity are uncoupled

TAD边界与基因活性脱钩

Almansour, Faisal; Fursova, Nadezda A; Keikhosravi, Adib; Reed, Kathleen S Metz; Larson, Daniel R; Pegoraro, Gianluca; Misteli, Tom

Transcriptional profiling of Hutchinson-Gilford progeria patients identifies primary target pathways of progerin

对 Hutchinson-Gilford 早衰症患者的转录组分析揭示了早衰蛋白的主要靶通路

Vidak, Sandra; Kim, Sohyoung; Misteli, Tom

OptoLoop - an optogenetic tool to probe the functional role of genome organization

OptoLoop——一种用于探测基因组组织功能作用的光遗传学工具

Stortz, Martin; Keikhosravi, Adib; Pegoraro, Gianluca; Misteli, Tom

Protocol to measure transcriptional bursting of endogenous genes using high-throughput RNA-FISH

利用高通量RNA-FISH技术测量内源基因转录爆发的方案

Sood, Varun; Misteli, Tom

Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks

急性降解子介导的 RUNX1 丢失会重编程增强子活性,从而通过表观遗传学驱动上皮不稳定并启动癌症特征。

Fritz, Andrew J; Greenyer, Haley; Dillac, Louis; Chavarkar, Priyanka; Ullah, Rahim; Malik, Miles; Hong, Deli; Toor, Rabail; Pacht, Emory; Person, Abigail G; Zotkin, Georgiy; Korzec, Sadie; Gao, Cong; Abuorquob, Alquassem; Warren, Janine; Del Porto, Jackson; Perelman, Jonah; Montecino, Martin; Lian, Jane B; Van Wijnen, Andre; Heath, Jessica; Ghule, Prachi; Frietze, Seth; Stengel, Kristy; Hiebert, Scott; Reed, Kathleen; Misteli, Tom; Gordon, Jonathan A; Stein, Janet L; Stein, Gary S

Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens.

利用高通量成像筛选鉴定基因特异性爆发模式的分子决定因素

Sood Varun, Holewinski Ronald, Andresson Thorkell, Larson Daniel R, Misteli Tom

Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy

通过优化的对羟基苄基连接基实现β-拉帕酮的可控自毁释放,用于靶向胰腺癌治疗

Becher, Julie B; Dutta, Nisita; Navo, Claudio D; Dunsmore, Lavinia; Misteli, Roman; Gil de Montes, Enrique; Simpson, Grant G; Alewine, Christine C; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo J L

Zooming in the plastisphere: the ecological interface for phytoplankton-plastic interactions in aquatic ecosystems

聚焦塑料圈:水生生态系统中浮游植物与塑料相互作用的生态界面

Nava, Veronica; Dar, Jaffer Y; De Santis, Vanessa; Fehlinger, Lena; Pasqualini, Julia; Adekolurejo, Oloyede A; Burri, Bryan; Cabrerizo, Marco J; Chonova, Teofana; Cour, Mathilde; Dory, Flavia; Drost, Annemieke M; Figler, Aida; Gionchetta, Giulia; Halabowski, Dariusz; Harvey, Daniel R; Manzanares-Vázquez, Víctor; Misteli, Benjamin; Mori-Bazzano, Laureen; Moser, Valentin; Rotta, Federica; Schmid-Paech, Bianca; Touchet, Camille M; Gostyńska, Julia