Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks
急性降解子介导的 RUNX1 丢失会重编程增强子活性，从而通过表观遗传学驱动上皮不稳定并启动癌症特征。
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doi:10.64898/2026.03.26.711344
Fritz, Andrew J; Greenyer, Haley; Dillac, Louis; Chavarkar, Priyanka; Ullah, Rahim; Malik, Miles; Hong, Deli; Toor, Rabail; Pacht, Emory; Person, Abigail G; Zotkin, Georgiy; Korzec, Sadie; Gao, Cong; Abuorquob, Alquassem; Warren, Janine; Del Porto, Jackson; Perelman, Jonah; Montecino, Martin; Lian, Jane B; Van Wijnen, Andre; Heath, Jessica; Ghule, Prachi; Frietze, Seth; Stengel, Kristy; Hiebert, Scott; Reed, Kathleen; Misteli, Tom; Gordon, Jonathan A; Stein, Janet L; Stein, Gary S
