日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

SPIDR能够对RNA-蛋白质相互作用进行多重映射,并揭示细胞应激下选择性翻译抑制的机制。

Erica Wolin ,Jimmy K Guo ,Mario R Blanco ,Isabel N Goronzy ,Darvesh Gorhe ,Wenzhao Dong ,Andrew A Perez ,Abdurrahman Keskin ,Elizabeth Valenzuela ,Ahmed A Abdou ,Carl R Urbinati ,Ross Kaufhold ,H Tomas Rube ,Jailson Brito Querido ,Mitchell Guttman ,Marko Jovanovic

Genome organization around nuclear speckles drives mRNA splicing efficiency

核斑点周围的基因组组织决定了 mRNA 剪接效率

Prashant Bhat, Amy Chow, Benjamin Emert, Olivia Ettlin, Sofia A Quinodoz, Mackenzie Strehle, Yodai Takei, Alex Burr, Isabel N Goronzy, Allen W Chen, Wesley Huang, Jose Lorenzo M Ferrer, Elizabeth Soehalim, Say-Tar Goh, Tara Chari, Delaney K Sullivan, Mario R Blanco, Mitchell Guttman

The genomic and cellular basis of biosynthetic innovation in rove beetles

隐翅虫生物合成创新的基因组和细胞基础

Sheila A Kitchen,Thomas H Naragon,Adrian Brückner,Mark S Ladinsky,Sofia A Quinodoz,Jean M Badroos,Joani W Viliunas,Yuriko Kishi,Julian M Wagner,David R Miller,Mina Yousefelahiyeh,Igor A Antoshechkin,K Taro Eldredge,Stacy Pirro,Mitchell Guttman,Steven R Davis,Matthew L Aardema,Joseph Parker

ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements

ChIP-DIP技术可同时绘制数百种蛋白质与DNA的结合图谱,并识别多种基因调控元件。

Andrew A Perez # ,Isabel N Goronzy # ,Mario R Blanco ,Benjamin T Yeh ,Jimmy K Guo ,Carolina S Lopes ,Olivia Ettlin ,Alex Burr ,Mitchell Guttman

Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo

变性纯化实验表明,PRC2 和其他广泛报道的染色质蛋白似乎并不在体内直接与 RNA 结合。

Jimmy K Guo ,Mario R Blanco ,Ward G Walkup 4th ,Grant Bonesteele ,Carl R Urbinati ,Abhik K Banerjee ,Amy Chow ,Olivia Ettlin ,Mackenzie Strehle ,Parham Peyda ,Enrique Amaya ,Vickie Trinh ,Mitchell Guttman

Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

针对病毒 RNA 的肽结合吗啉低聚物抑制小鼠肺中 SARS-CoV-2 的生长

Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolf

SPIDR: a highly multiplexed method for mapping RNA-protein interactions uncovers a potential mechanism for selective translational suppression upon cellular stress

SPIDR:一种用于映射 RNA-蛋白质相互作用的高度多路复用方法揭示了细胞应激时选择性翻译抑制的潜在机制

Erica Wolin, Jimmy K Guo, Mario R Blanco, Andrew A Perez, Isabel N Goronzy, Ahmed A Abdou, Darvesh Gorhe, Mitchell Guttman, Marko Jovanovic

Single-cell measurement of higher-order 3D genome organization with scSPRITE

使用 scSPRITE 对高阶三维基因组组织进行单细胞测量

Mary V Arrastia #, Joanna W Jachowicz #, Noah Ollikainen, Matthew S Curtis, Charlotte Lai, Sofia A Quinodoz, David A Selck, Rustem F Ismagilov, Mitchell Guttman

SPRITE: a genome-wide method for mapping higher-order 3D interactions in the nucleus using combinatorial split-and-pool barcoding

SPRITE:一种利用组合式分裂-混合条形码技术绘制细胞核内高级三维相互作用的全基因组方法。

Sofia A Quinodoz ,Prashant Bhat ,Peter Chovanec ,Joanna W Jachowicz ,Noah Ollikainen ,Elizabeth Detmar ,Elizabeth Soehalim ,Mitchell Guttman

Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome

Xist 在空间上放大 SHARP/SPEN 募集,以平衡染色体范围内的沉默和 X 染色体的特异性

Joanna W Jachowicz #, Mackenzie Strehle #, Abhik K Banerjee, Mario R Blanco, Jasmine Thai, Mitchell Guttman