Mitchell Ho相关文献与解析，生知库 | 链接生命科学的每一步

Alex Quan ，Mingyu Huo ，Dan Li ，Laura E Hutchins ，Constanza Rodriguez ，Jangsuk Oh ，Hsi-En Tsao ，Madeline Spetz ，Elijah Edmondson ，Dana Ashworth ，Rui Zheng ，Jing Zhou ，Jinyun Chen ，Jingbao Liu ，Guangyan Xiong ，Hongbing Zhang ，Cheng Liu ，Rosa Nguyen ，Nan Li ，Mitchell Ho

神经科学

T Cell Receptor

T细胞

发表日期：2025

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GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma

经NFAT诱导的膜锚定IL15/IL21改造的GPC2靶向CAR T细胞对神经母细胞瘤表现出增强的活性

期刊:Cancer Immunology Research

影响因子:8.1

doi:10.1158/2326-6066.CIR-24-0975

Reona Okada ，Jeyshka M Reyes-González ，Constanza Rodriguez ，Taisuke Kondo ，Jangsuk Oh ，Ming Sun ，Michael C Kelly ，Ling Zhang ，James Gulley ，Jack F Shern ，Mitchell Ho ，Christian S Hinrichs ，Naomi N Taylor ，Xiyuan Zhang ，Rosa Nguyen

Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling

带有亮氨酸拉链的模块化嵌合细胞因子受体通过 JAK/STAT 信号传导增强 CAR-T 细胞的抗肿瘤活性

期刊:Nature Biomedical Engineering

影响因子:26.8

doi:10.1038/s41551-023-01143-w

Matthew Bell, Shannon Lange, Besian I Sejdiu, Jorge Ibanez, Hao Shi, Xiang Sun, Xiaoxi Meng, Phuong Nguyen, Morgan Sutton, Jessica Wagner, Anil Kc, Deanna Langfitt, Sagar L Patil, Haiyan Tan, Ram Vinay Pandey, Yuxin Li, Zuo-Fei Yuan, Alejandro Allo Anido, Mitchell Ho, Heather Sheppard, Peter Vogel,

rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors

rhIL-7-hyFc 是一种长效白细胞介素 7，可提高 CAR-T 细胞治疗实体肿瘤的疗效

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.3

doi:10.1136/jitc-2024-008989

Dan Li, Tianyuzhou Liang, Laura E Hutchins, Alexandra A Wolfarth, Sara Ferrando-Martinez, Byung Ha Lee, Mitchell Ho

Cooperative Armoring of CAR and TCR T Cells by T Cell-Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy

T细胞限制性IL15和IL21对CAR和TCR T细胞的协同保护作用可普遍增强实体瘤疗效

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-23-1872

Rosa Nguyen # ，Ekaterina Doubrovina # ，Charlotte M Mousset ，Benjamin Y Jin ，Reona Okada ，Xiyuan Zhang ，Arina Clavel ，Jeyshka M Reyes-Gonzalez ，Vadim Dyomin ，Louis Diaz ，Ling Zhang ，Shahroze Abbas ，Ming Sun ，Chao-Ming Hsieh ，Mitchell Ho ，Jack F Shern ，James L Gulley ，Christian S Hinrichs

CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer

基于靶向 HPV16 E6 的 TCR 模拟纳米抗体的 CAR-T 细胞对宫颈癌表现出抗肿瘤活性

期刊:Molecular Therapy Oncology

影响因子:4.5

doi:10.1016/j.omton.2024.200892

Zhijian Duan, Dan Li, Nan Li, Shaoli Lin, Hua Ren, Jessica Hong, Christian S Hinrichs, Mitchell Ho

Adjuvants to the S1-subunit of the SARS-CoV-2 spike protein vaccine improve antibody and T cell responses and surrogate neutralization in mice

SARS-CoV-2 刺突蛋白疫苗 S1 亚基的佐剂可改善小鼠的抗体和 T 细胞反应以及替代中和作用

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-024-80636-3

William Becker, Khadija Rebbani, Zhijian Duan, Eugene Valkov, Shawn Bryant, Mitchell Ho, Jay A Berzofsky, Purevdorj B Olkhanud

The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

IgG4铰链区与CD28跨膜结构域结合，可增强靶向胰腺癌中GPC1膜远端表位的VHH基CAR-T细胞的疗效。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-37616-4

Nan Li ，Alex Quan ，Dan Li ，Jiajia Pan ，Hua Ren ，Gerard Hoeltzel ，Natalia de Val ，Dana Ashworth ，Weiming Ni ，Jing Zhou ，Sean Mackay ，Stephen M Hewitt ，Raul Cachau ，Mitchell Ho

Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

基于骆驼纳米抗体的 B7-H3 CAR-T 细胞对大型实体肿瘤表现出高效性

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-41631-w

Dan Li, Ruixue Wang, Tianyuzhou Liang, Hua Ren, Chaelee Park, Chin-Hsien Tai, Weiming Ni, Jing Zhou, Sean Mackay, Elijah Edmondson, Javed Khan, Brad St Croix, Mitchell Ho

Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

针对神经母细胞瘤的GPC2靶向CAR T细胞疗法的临床前优化

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.3

doi:10.1136/jitc-2022-005881

Ming Sun ，Yingying Cao ，Reona Okada ，Jeyshka M Reyes-González ，Hannah G Stack ，Haiying Qin ，Nan Li ，Charlie Seibert ，Michael C Kelly ，Eytan Ruppin ，Mitchell Ho ，Carol J Thiele ，Rosa Nguyen

Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

靶向GPC2的抗体-γ/δ T细胞受体可使低抗原密度神经母细胞瘤消退

GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma

经NFAT诱导的膜锚定IL15/IL21改造的GPC2靶向CAR T细胞对神经母细胞瘤表现出增强的活性

Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling

带有亮氨酸拉链的模块化嵌合细胞因子受体通过 JAK/STAT 信号传导增强 CAR-T 细胞的抗肿瘤活性

rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors

rhIL-7-hyFc 是一种长效白细胞介素 7，可提高 CAR-T 细胞治疗实体肿瘤的疗效

Cooperative Armoring of CAR and TCR T Cells by T Cell-Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy

T细胞限制性IL15和IL21对CAR和TCR T细胞的协同保护作用可普遍增强实体瘤疗效

CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer

基于靶向 HPV16 E6 的 TCR 模拟纳米抗体的 CAR-T 细胞对宫颈癌表现出抗肿瘤活性

Adjuvants to the S1-subunit of the SARS-CoV-2 spike protein vaccine improve antibody and T cell responses and surrogate neutralization in mice

SARS-CoV-2 刺突蛋白疫苗 S1 亚基的佐剂可改善小鼠的抗体和 T 细胞反应以及替代中和作用

The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

IgG4铰链区与CD28跨膜结构域结合，可增强靶向胰腺癌中GPC1膜远端表位的VHH基CAR-T细胞的疗效。

Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

基于骆驼纳米抗体的 B7-H3 CAR-T 细胞对大型实体肿瘤表现出高效性

Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

针对神经母细胞瘤的GPC2靶向CAR T细胞疗法的临床前优化