日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Aspects of Mycobacterium tuberculosis DNA Gyrase Targeted by Novel Bacterial Topoisomerase Inhibitors

新型细菌拓扑异构酶抑制剂靶向结核分枝杆菌DNA旋转酶的结构特征

Kokot, Maja; Hrast Rambaher, Martina; Feng, Lipeng; Mitchenall, Lesley A; Lawson, David M; Maxwell, Anthony; Parish, Tanya; Minovski, Nikola; Anderluh, Marko

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

通过碱基对分辨率分析超螺旋对 DNA 柔韧性和三链形成寡核苷酸大沟识别的影响

Alice L B Pyne #, Agnes Noy #, Kavit H S Main, Victor Velasco-Berrelleza, Michael M Piperakis, Lesley A Mitchenall, Fiorella M Cugliandolo, Joseph G Beton, Clare E M Stevenson, Bart W Hoogenboom, Andrew D Bates, Anthony Maxwell, Sarah A Harris4

Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase

对靶向分枝杆菌DNA促旋酶的ATPase抑制剂进行结构和机制分析

Henderson, Sara R; Stevenson, Clare E M; Malone, Brandon; Zholnerovych, Yelyzaveta; Mitchenall, Lesley A; Pichowicz, Mark; McGarry, David H; Cooper, Ian R; Charrier, Cedric; Salisbury, Anne-Marie; Lawson, David M; Maxwell, Anthony

A rapid high-resolution method for resolving DNA topoisomers

一种快速高分辨率解析DNA拓扑异构体的方法

Mitchenall, Lesley A; Hipkin, Rachel E; Piperakis, Michael M; Burton, Nicolas P; Maxwell, Anthony

DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana

DNA 旋转酶是拟南芥中喹诺酮类药物环丙沙星的靶标

Katherine M Evans-Roberts, Lesley A Mitchenall, Melisa K Wall, Julie Leroux, Joshua S Mylne, Anthony Maxwell

DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases

DNA G片段弯曲并非II型DNA拓扑异构酶简化DNA拓扑结构的唯一决定因素

Thomson, Neil H; Santos, Sergio; Mitchenall, Lesley A; Stuchinskaya, Tanya; Taylor, James A; Maxwell, Anthony

The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action

萘醌二吡啶是一种具有新作用机制的 DNA 旋转酶抑制剂

Shantanu Karkare, Terence T H Chung, Frederic Collin, Lesley A Mitchenall, Adam R McKay, Sandra J Greive, Jacobus J M Meyer, Namrita Lall, Anthony Maxwell

Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI

应用一种新型的基于微孔板的检测方法发现DNA促旋酶和DNA拓扑异构酶VI的新抑制剂

Taylor, James A; Mitchenall, Lesley A; Rejzek, Martin; Field, Robert A; Maxwell, Anthony

A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions

通过对毒素/靶标和毒素/抗毒素相互作用的分析,可以推测细菌毒素-抗毒素系统 parD 和 ccd 具有共同的起源

Andrew B Smith, Juan López-Villarejo, Elizabeth Diago-Navarro, Lesley A Mitchenall, Arjan Barendregt, Albert J Heck, Marc Lemonnier, Anthony Maxwell, Ramón Díaz-Orejas

The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage

GyrB 的二聚体状态是一种活性形式:对初始复合物组装和加工链通道的影响

Jinjun Wu, Zhiping Zhang, Lesley A Mitchenall, Anthony Maxwell, Jiaoyu Deng, Hongtai Zhang, Ying Zhou, Yuan-Yuan Chen, Da-Cheng Wang, Xian-En Zhang, Lijun Bi