日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Heteroduplex oligonucleotide technology boosts gene knockdown in cardiac and skeletal muscles

异源双链寡核苷酸技术可增强心肌和骨骼肌中的基因敲低效果

Sakino Matsuda-Kawabata,Tetsuya Nagata,Mitsugu Yanagidaira,Kensuke Ihara,Masaki Ohyagi,Hidetoshi Kaburagi,Kie Yoshida-Tanaka,Asuka Sasaki,Aya Abe,Satoe Ebihara,Juri Hasegawa,Nozomi Toide,Masahiro Ohara,Mitsuru Naito,Kanjiro Miyata,Kazuko Toh,Fumika Sakaue,Takanori Yokota

Immunological profile of the tumor immune microenvironment of upper tract urothelial carcinoma predicts recurrence patterns

上尿路尿路上皮癌肿瘤免疫微环境的免疫学特征可预测复发模式

Kenta Takahashi #,Daiki Ikarashi #,Shigehisa Kitano #,Daichi Tamura,Masakazu Abe,Ayato Ito,Ei Shiomi,Shigekatsu Maekawa,Renpei Kato,Mitsugu Kanehira,Naoki Yanagawa,Wataru Obara #

Safety and effectiveness of post-trastuzumab deruxtecan regimens in patients with HER2-positive metastatic breast cancer who discontinued trastuzumab deruxtecan due to interstitial lung disease

因间质性肺病而停用曲妥珠单抗德鲁替康的HER2阳性转移性乳腺癌患者,在停用曲妥珠单抗德鲁替康后,后续治疗方案的安全性和有效性

Tsurutani, Junji; Nozawa, Kazuki; Mukohara, Toru; Taira, Tetsuhiko; Yoshimura, Akiyo; Nagai, Shigenori E; Hashimoto, Jun; Matsuura, Kazuo; Mizuno, Toshiro; Shinden, Yoshiaki; Yamamoto, Mitsugu; Takano, Toshimi; Wakahara, Makoto; Terakawa, Hirofumi; Yamanaka, Takashi; Kojima, Yasuyuki; Nakayama, Takahiro; Hirakawa, Yuji; Shiosakai, Kazuhito; Iwata, Hiroji

C-Ring Structure-Dependent Redox Properties of Flavonoids Regulate the Expression of Bioactivity

黄酮类化合物的C环结构依赖性氧化还原性质调控其生物活性的表达

Fushimi, Taiki; Aso, Kenta; Shimizu, Takafumi; Hirahata, Chie; Hiroki, Kento; Shinmura, Daichi; Fujii, Yasuyuki; Akagawa, Mitsugu; Abdelhameed, Ali S; Calabrese, Vittorio; Taira, Shu; Suhara, Yoshitomo; Osakabe, Naomi

Two Cases of CLIPPERS-like Syndrome Sharing a Hypomorphic UNC13D Variant

两例类似 CLIPPERS 综合征的病例共享一个功能减弱的 UNC13D 变异

Sagawa, Hirotaka; Hirata, Kosei; Katayama, Saori; Shibata, Hirofumi; Toyofuku, Etsushi; Kaneko, Shuya; Katata, Yu; Takezawa, Yusuke; Uematsu, Mitsugu; Onishi, Iichiroh; Yamazaki, Yuto; Hattori, Takaaki; Yamamoto, Masahide; Shimizu, Masaki; Imai, Kohsuke; Yasumi, Takahiro; Morio, Tomohiro; Yokota, Takanori; Sasahara, Yoji; Kanegane, Hirokazu

Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells

缺氧和阿司匹林对PIK3CA突变型结直肠癌细胞的细胞内谷氨酰胺积累具有叠加效应。

Umezaki, Nodoka; Boku, Shogen; Matsuo, Yoshiyuki; Yamamoto, Tetsushi; Satake, Hironaga; Watanabe, Motoki; Hirota, Kiichi; Sugie, Tomoharu; Sekimoto, Mitsugu

Functional Analysis of a Novel Pathogenic Glycine Amidinotransferase Mutant in Hereditary Fanconi Syndrome

遗传性范可尼综合征中一种新型致病性甘氨酸脒基转移酶突变体的功能分析

Takayanagi, Shunsuke; Mori, Keita P; Kang, Youngna; Araki, Mitsugu; Matsumoto, Shigeyuki; Sagae, Yukari; Sakakibara, Nana; Horinouchi, Tomoko; Higashi, Yoshiaki; Endo, Tomomi; Muso, Eri; Nozu, Kandai; Okuno, Yasushi; Yanagita, Motoko; Matsubara, Takeshi; Tsukamoto, Tatsuo

Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection

吗啉代RNA双链体通过脑室内和鞘内注射表现出强效、持久且安全的空间位阻反义活性。

Yanagidaira, Mitsugu; Nagata, Tetsuya; Hasegawa, Juri; Ishii, Takashi; Ebihara, Satoe; Nawa, Makiko; Yokota, Takanori

Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities

肺腺癌中CMTR2基因突变改变RNA选择性剪接并揭示治疗弱点

Shigenari Nukaga ,Kouya Shiraishi ,Kenta Hamabe ,Akifumi Mochizuki ,Yu Hamaguchi ,Emi Ogawa ,Nguyen Thai Le ,Yoko Shimada ,Hanako Ono ,Hitomi Nishinakamura ,Yoshihisa Kobayashi ,Junko Hamamoto ,Ayako Ui ,Mitsugu Araki ,Yukari Sagae ,Keiko Ohgino ,Kai Sugihara ,Satoshi Endo ,Jun Miyakoshi ,Yuichi Shiraishi ,Hiroyuki Yasuda ,Yasushi Okuno ,Tatsuya Yoshida ,Yasushi Goto ,Yuichiro Ohe ,Shun-Ichi Watanabe ,Yasushi Yatabe ,Hiroyoshi Nishikawa ,Ryuji Hamamoto ,Takashi Kohno ,Takashi Nakaoku

MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism

MLX 磷酸化可稳定串联 E 盒上的 ChREBP-MLX 异四聚体,从而控制碳水化合物和脂质代谢

Carla E Cadena Del Castillo, Onur Deniz, Femke van Geest, Lore Rosseels, Ingrid Stockmans, Marius Robciuc, Sebastien Carpentier, Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach, Ralph Peterli, Ville Hietakangas, Mitsugu Shimobayashi