日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combinatorial optimization of the hybrid cellulase complex structure designed from modular libraries

从模块库设计的混合纤维素酶复合物结构的组合优化

Hikaru Nakazawa, Izumi Okada, Tomoyuki Ito, Yuri Ishigaki, Izumi Kumagai, Mitsuo Umetsu

Extensive antibody search with whole spectrum black-box optimization

利用全谱黑盒优化进行广泛的抗体搜索

Andrejs Tučs #, Tomoyuki Ito #, Yoichi Kurumida, Sakiya Kawada, Hikaru Nakazawa, Yutaka Saito, Mitsuo Umetsu, Koji Tsuda1

Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning

通过深度测序和机器学习从弱富集噬菌体展示文库信息中选择靶标结合蛋白

Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu

A streamlined strain engineering workflow with genome-wide screening detects enhanced protein secretion in Komagataella phaffii

通过全基因组筛选,简化的菌株工程工作流程可检测到毕赤酵母中增强的蛋白质分泌。

Yoichiro Ito,Misa Ishigami,Goro Terai,Yasuyuki Nakamura,Noriko Hashiba,Teruyuki Nishi,Hikaru Nakazawa,Tomohisa Hasunuma,Kiyoshi Asai,Mitsuo Umetsu,Jun Ishii,Akihiko Kondo

Rational thermostabilisation of four-helix bundle dimeric de novo proteins

四螺旋束二聚体新生蛋白的合理热稳定化

Shin Irumagawa, Kaito Kobayashi, Yutaka Saito, Takeshi Miyata, Mitsuo Umetsu, Tomoshi Kameda, Ryoichi Arai

Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

通过整合高亲和力突变体和功能性分子形式构建抗 EGFR × 抗 CD3 双特异性双抗体的功能化

Ryutaro Asano, Katsuhiro Hosokawa, Shintaro Taki, Shota Konno, Ippei Shimomura, Hiromi Ogata, Mai Okada, Kyoko Arai, Masayoshi Onitsuka, Takeshi Omasa, Takeshi Nakanishi, Mitsuo Umetsu, Izumi Kumagai

Chemically Crosslinked Bispecific Antibodies for Cancer Therapy: Breaking from the Structural Restrictions of the Genetic Fusion Approach

化学交联双特异性抗体用于癌症治疗:突破基因融合方法的结构限制

Asami Ueda, Mitsuo Umetsu, Takeshi Nakanishi, Kentaro Hashikami, Hikaru Nakazawa, Shuhei Hattori, Ryutaro Asano, Izumi Kumagai

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity

从结构域顺序和结合亲和力的角度考虑功能性抗 EGFR × 抗 CD3 双特异性双抗体的结构

Ryutaro Asano, Keisuke Nagai, Koki Makabe, Kento Takahashi, Takashi Kumagai, Hiroko Kawaguchi, Hiromi Ogata, Kyoko Arai, Mitsuo Umetsu, Izumi Kumagai

Anti-EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half-life

抗EGFR scFv四聚体(四体),具有稳定的单分散结构、强的抗癌作用和较长的体内半衰期

Ryutaro Asano, Noriaki Koyama, Yasuyo Hagiwara, Yosuke Masakari, Ryota Orimo, Kyoko Arai, Hiromi Ogata, Shozo Furumoto, Mitsuo Umetsu, Izumi Kumagai

Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

重新排列基于双抗体的 IgG 样双特异性抗体的结构域顺序可增强其抗肿瘤活性并改善其抗降解性和药代动力学

Ryutaro Asano, Ippei Shimomura, Shota Konno, Akiko Ito, Yosuke Masakari, Ryota Orimo, Shintaro Taki, Kyoko Arai, Hiromi Ogata, Mai Okada, Shozo Furumoto, Masayoshi Onitsuka, Takeshi Omasa, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Mitsuo Umetsu, Izumi Kumagai