日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques

一种可释放三种抗病毒药物和一种避孕药的阴道环,能够阻断SHIV-RT感染,减少HSV-2病毒脱落,并抑制恒河猴的激素周期。

Derby, Nina; Aravantinou, Meropi; Kenney, Jessica; Ugaonkar, Shweta R; Wesenberg, Asa; Wilk, Jolanta; Kizima, Larisa; Rodriguez, Aixa; Zhang, Shimin; Mizenina, Olga; Levendosky, Keith; Cooney, Michael L; Seidor, Samantha; Gettie, Agegnehu; Grasperge, Brooke; Blanchard, James; Piatak, Michael Jr; Lifson, Jeffrey D; Fernández-Romero, José; Zydowsky, Thomas M; Robbiani, Melissa

Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques

在感染猴免疫缺陷病毒(SIV)的恒河猴中,实验性口腔单纯疱疹病毒-1(HSV-1)合并感染

Aravantinou, Meropi; Mizenina, Olga; Calenda, Giulia; Kenney, Jessica; Frank, Ines; Lifson, Jeffrey D; Szpara, Moriah; Jing, Lichen; Koelle, David M; Teleshova, Natalia; Grasperge, Brooke; Blanchard, James; Gettie, Agegnehu; Martinelli, Elena; Derby, Nina

In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa

体外暴露于PC-1005和阴道给药PC-1005女性的宫颈阴道灌洗液可抑制人宫颈黏膜中的HIV-1和HSV-2感染

Villegas, Guillermo; Calenda, Giulia; Zhang, Shimin; Mizenina, Olga; Kleinbeck, Kyle; Cooney, Michael L; Hoesley, Craig J; Creasy, George W; Friedland, Barbara; Fernández-Romero, José A; Zydowsky, Thomas M; Teleshova, Natalia

A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo

一种新型的杀微生物剂/避孕阴道环可在体外保护猕猴生殖器黏膜免受SHIV-RT感染

Villegas, Guillermo; Calenda, Giulia; Ugaonkar, Shweta; Zhang, Shimin; Kizima, Larisa; Mizenina, Olga; Gettie, Agegnehu; Blanchard, James; Cooney, Michael L; Robbiani, Melissa; Fernández-Romero, José A; Zydowsky, Thomas M; Teleshova, Natalia

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

通过高剂量阴道环暴露于 MIV-150 会导致感染 SHIV-RT 的恒河猴出现有限的耐药突变。

Hsu, Mayla; Keele, Brandon F; Aravantinou, Meropi; Krawczyk, Noa; Seidor, Samantha; Abraham, Ciby J; Zhang, Shimin; Rodriguez, Aixa; Kizima, Larisa; Derby, Nina; Jean-Pierre, Ninochka; Mizenina, Olga; Gettie, Agegnehu; Grasperge, Brooke; Blanchard, James; Piatak, Michael J Jr; Lifson, Jeffrey D; Fernández-Romero, José A; Zydowsky, Thomas M; Robbiani, Melissa

A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.

在体内,一部分树突状细胞通过一种不依赖于IL-12但依赖于CD70的机制诱导CD4+ T细胞产生IFN-γ

Soares Helena, Waechter HaeNa, Glaichenhaus Nicholas, Mougneau Evelyne, Yagita Hideo, Mizenina Olga, Dudziak Diana, Nussenzweig Michel C, Steinman Ralph M