Mobarec相关文献与解析，生知库 | 链接生命科学的每一步

Topology-driven negative sampling enhances generalizability in protein-protein interaction prediction

基于拓扑结构的负采样增强了蛋白质-蛋白质相互作用预测的泛化能力

Chatterjee, Ayan; Ravandi, Babak; Haddadi, Parham; Philip, Naomi H; Abdelmessih, Mario; Mowrey, William R; Ricchiuto, Piero; Liang, Yupu; Ding, Wei; Mobarec, Juan Carlos; Eliassi-Rad, Tina

发表日期：2025

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The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction

雄激素球蛋白的环状排列球蛋白结构域表现出非典型的血红素稳定作用和一氧化氮相互作用。

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d4sc00953c

Reeder, Brandon J; Deganutti, Giuseppe; Ukeri, John; Atanasio, Silvia; Svistunenko, Dimitri A; Ronchetti, Christopher; Mobarec, Juan Carlos; Welbourn, Elizabeth; Asaju, Jeffrey; Vos, Marten H; Wilson, Michael T; Reynolds, Christopher A

免疫/内分泌

发表日期：2024

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Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations

利用自由能微扰计算对蛋白质-蛋白质复合物突变的相对结合能进行稳健预测

期刊:Journal of Molecular Biology

影响因子:4.5

doi:10.1016/j.jmb.2024.168640

Sampson, Jared M; Cannon, Daniel A; Duan, Jianxin; Epstein, Jordan C K; Sergeeva, Alina P; Katsamba, Phinikoula S; Mannepalli, Seetha M; Bahna, Fabiana A; Adihou, Hélène; Guéret, Stéphanie M; Gopalakrishnan, Ranganath; Geschwindner, Stefan; Rees, D Gareth; Sigurdardottir, Anna; Wilkinson, Trevor; Dodd, Roger B; De Maria, Leonardo; Mobarec, Juan Carlos; Shapiro, Lawrence; Honig, Barry; Buchanan, Andrew; Friesner, Richard A; Wang, Lingle

发表日期：2024

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Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

利用自由能微扰计算对蛋白质-蛋白质复合物突变的相对结合能进行稳健预测

期刊:

影响因子:

doi:10.1101/2024.04.22.590325

发表日期：2024

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Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases

对酶库的分析揭示了自然进化的[4+2]环化酶的催化可塑性

期刊:Chembiochem

影响因子:2.8

doi:10.1002/cbic.202300382

Zorn, Katja; Back, Catherine R; Barringer, Rob; Chadimová, Veronika; Manzo-Ruiz, Monserrat; Mbatha, Sbusisiwe Z; Mobarec, Juan-Carlos; Williams, Sam E; van der Kamp, Marc W; Race, Paul R; Willis, Christine L; Hayes, Martin A

发表日期：2023

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Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia

间歇性低压缺氧诱导的心脏保护抗氧化和抗炎机制

期刊:Antioxidants

影响因子:

doi:10.3390/antiox11061043

Alejandro González-Candia, Alejandro A Candia, Adolfo Paz, Fuad Mobarec, Rodrigo Urbina-Varela, Andrea Del Campo, Emilio A Herrera, Rodrigo L Castillo

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

降钙素基因相关肽和肾上腺髓质素受体与 Gs 偶联的受体活性修饰蛋白依赖性和独立性激活机制

期刊:Biochemical Pharmacology

影响因子:5.3

doi:10.1016/j.bcp.2017.07.005

Michael J Woolley, Christopher A Reynolds, John Simms, Christopher S Walker, Juan Carlos Mobarec, Michael L Garelja, Alex C Conner, David R Poyner, Debbie L Hay

表观遗传

发表日期：2017

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High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

肽激动剂 TIP-39 与甲状旁腺激素 2 (PTH2) 受体的高亲和力结合需要跨膜螺旋 5 上的 Tyr-318 羟基

期刊:Biochemical Pharmacology

影响因子:5.3

doi:10.1016/j.bcp.2016.12.013

Richard E Weaver, Juan C Mobarec, Mark J Wigglesworth, Christopher A Reynolds, Dan Donnelly

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

基因编码的光交联剂决定了完整的人类胰高血糖素样肽-1 受体 (GLP-1R) 的 N 端结构域中艾塞那肽-4 肽的生物结合位点

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1074/jbc.M117.779496

Cassandra Koole, Christopher A Reynolds, Juan C Mobarec, Caroline Hick, Patrick M Sexton, Thomas P Sakmar

Quantifying Cooperativity through Binding Free Energies in Molecular Glue Degraders

通过分子胶降解剂中的结合自由能量化协同性

Topology-driven negative sampling enhances generalizability in protein-protein interaction prediction

基于拓扑结构的负采样增强了蛋白质-蛋白质相互作用预测的泛化能力

The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction

雄激素球蛋白的环状排列球蛋白结构域表现出非典型的血红素稳定作用和一氧化氮相互作用。

Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations

利用自由能微扰计算对蛋白质-蛋白质复合物突变的相对结合能进行稳健预测

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

利用自由能微扰计算对蛋白质-蛋白质复合物突变的相对结合能进行稳健预测

Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases

对酶库的分析揭示了自然进化的[4+2]环化酶的催化可塑性

Cardioprotective Antioxidant and Anti-Inflammatory Mechanisms Induced by Intermittent Hypobaric Hypoxia

间歇性低压缺氧诱导的心脏保护抗氧化和抗炎机制

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

降钙素基因相关肽和肾上腺髓质素受体与 Gs 偶联的受体活性修饰蛋白依赖性和独立性激活机制

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

肽激动剂 TIP-39 与甲状旁腺激素 2 (PTH2) 受体的高亲和力结合需要跨膜螺旋 5 上的 Tyr-318 羟基

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

基因编码的光交联剂决定了完整的人类胰高血糖素样肽-1 受体 (GLP-1R) 的 N 端结构域中艾塞那肽-4 肽的生物结合位点