日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent double-stranded RNA unwinding

MDA5通过ATP依赖的双链RNA解旋生成紧凑的核糖核蛋白复合物。

Quack, Salina; Maity, Sourav; America, Pim P B; Klein, Misha; Herrero Del Valle, Alba; Singh, Rahul; Joiner, Joe D; Rashid, Zainab M; Smitskamp, Quinte; Rivas, Paula; Papini, Flavia S; Broedersz, Chase P; Roos, Wouter H; Modis, Yorgo; Dulin, David

Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9

能够选择性降解BRD9的DCAF16募集靶向胶的作用机制

Scott J Hughes ,Wojciech J Stec ,Colin T R Davies ,David McGarry ,Alicia Williams ,Marta Carrara ,Ivan Del Barco Barrantes ,Rebecca Harris ,Anna Tasegian ,Dominic D G Owens ,Alexander Fawcett ,John Hellicar ,Aleksandra Azevedo ,Gregor P Meier ,Andrew C Runcie ,Liliana Greger ,Martin O'Rourke ,Ian Churcher ,Martin Pass ,Giles A Brown ,Alessio Ciulli ,Louise K Modis ,Andrea Testa

Molecular basis of autoimmune disease protection by MDA5 variants

MDA5 变体对自身免疫性疾病保护的分子基础

Singh, Rahul; Joiner, Joe D; Herrero Del Valle, Alba; Zwaagstra, Marleen; Jobe, Ida; Ferguson, Brian J; van Kuppeveld, Frank J M; Modis, Yorgo

MDA5 variants trade antiviral activity for protection from autoimmune disease

MDA5 变体以抗病毒活性换取对自身免疫性疾病的保护作用

Wallace, Chris; Singh, Rahul; Modis, Yorgo

Protocol for the expression, purification, and biochemical characterization of the innate immune sensor MDA5

先天免疫传感器MDA5的表达、纯化和生化表征方案

Joiner, Joe D; Herrero Del Valle, Alba; Singh, Rahul; Modis, Yorgo

The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

牛痘硫酸软骨素结合蛋白驱动宿主膜曲率以促进融合

Laura Pokorny, Jemima J Burden, David Albrecht, Rebecca Bamford, Kendra E Leigh, Pooja Sridhar, Timothy J Knowles, Yorgo Modis, Jason Mercer

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing

对比 MDA5 和 LGP2 在病毒 RNA 传感中的 ATP 水解功能

Rahul Singh, Yuan Wu, Alba Herrero Del Valle, Kendra E Leigh, Sai Mong, Mark T K Cheng, Brian J Ferguson, Yorgo Modis

Crystal structure and biochemical activity of the macrodomain from rubella virus p150.

风疹病毒p150宏结构域的晶体结构和生化活性

Stoll Guido A, Nikolopoulos Nikos, Zhai Haoming, Zhang Liao, Douse Christopher H, Modis Yorgo

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

NLRP3 激活的 ASC 复合物的低温电子断层扫描揭示了细胞器共定位

Yangci Liu, Haoming Zhai, Helen Alemayehu, Jérôme Boulanger, Lee J Hopkins, Alicia C Borgeaud, Christina Heroven, Jonathan D Howe, Kendra E Leigh, Clare E Bryant, Yorgo Modis

Antithrombin Activity Is Associated with Persistent Thromboinflammation and Mortality in Patients with Severe COVID-19 Illness

抗凝血酶活性与重症新冠肺炎患者的持续性血栓炎症和死亡率相关

Chen-Goodspeed, Amber; Dronavalli, Goutham; Zhang, Xu; Podbielski, Jeanette M; Patel, Bela; Modis, Katalin; Cotton, Bryan A; Wade, Charles E; Cardenas, Jessica C