日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

突破障碍：皮内注射脂多糖激发试验作为健康志愿者体内可控诱导血管渗漏的体内模型的特征分析

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70126
van Ruissen, Marella Cornelia Elizabeth; van Diemen, Menno; Botros, Liza; Tomljanovic, Ingrid; Achbo, Hind; Eleftheriou, Dimitra; Schenk, Paul Willem; Klarenbeek, Naomi Bertine; Gilroy, Derek William; Jansen, Manon Aleida Adriana; Moerland, Matthijs
发表日期：2026
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Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

健康立场文件和氧化还原视角——非传染性疾病中NRF2药物调控的从实验室到临床转化

期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2025.103569
Cuadrado, Antonio; Cazalla, Eduardo; Bach, Anders; Bathish, Boushra; Naidu, Sharadha Dayalan; DeNicola, Gina M; Dinkova-Kostova, Albena T; Fernández-Ginés, Raquel; Grochot-Przeczek, Anna; Hayes, John D; Kensler, Thomas W; León, Rafael; Liby, Karen T; López, Manuela G; Manda, Gina; Shivakumar, Akshatha Kalavathi; Hakomäki, Henriikka; Moerland, Jessica A; Motohashi, Hozumi; Rojo, Ana I; Sykiotis, Gerasimos P; Taguchi, Keiko; Valverde, Ángela M; Yamamoto, Masayuki; Levonen, Anna-Liisa
信号转导
NRF2
发表日期：2025
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Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis.

多发性硬化症中髓鞘再生效率高低与否，可通过不同的转录变化来区分

期刊:Brain
影响因子:11.7
doi:10.1093/brain/awae414
Chen J Q Alida, McNamara Niamh B, Engelenburg Hendrik J, Jongejan Aldo, Wever Dennis D, Hopman Kaya, van Rixel Esmée, Nijhuis Paul J H, de Winter Fred, Moerland Perry D, Smolders Joost, Verhaagen Joost, Hamann Jörg, Huitinga Inge
其它
发表日期：2025
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Synthetic Oleanane Triterpenoids Reduce Tumor Growth and Promote an Anti-Tumor Immune Response Independent of Cancer KEAP1 Mutational Status.

合成齐墩果烷三萜类化合物可减少肿瘤生长并促进抗肿瘤免疫反应，且与癌症 KEAP1 突变状态无关。

期刊:Antioxidants
影响因子:6.6
doi:10.3390/antiox14121406
Occhiuto Christopher J, Moerland Jessica A, Liby Karen T, Leal Ana S
KEAP1
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2025
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POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study

POLB 001（一种 p38 MAPK 抑制剂）可降低健康志愿者体内注射 LPS 后引起的局部和全身炎症反应：一项随机、双盲、安慰剂对照研究

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1684307
de Bruin, Digna T; Jansen, Manon A A; Pereira, Diana R; van Schijndel, Lisa; Klaassen, Erica S; Otto, Marije E; Skillington, Jeremy; Maguire, Paula; Tremble, Liam; Bell, Alan; Maher, Laura; Mihara, Katsuhiro; Sumeray, Mark; Gilroy, Derek W; Klarenbeek, Naomi B; Moerland, Matthijs
炎症/感染
炎症
p38 MAPK
MAPK/ERK
发表日期：2025
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Correction: Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response

更正：对阿尔茨海默病抵抗个体的基因表达谱分析显示，与金属硫蛋白和线粒体过程相关的基因表达水平较高，而未折叠蛋白反应没有变化。

期刊:Acta Neuropathologica Communications
影响因子:5.7
doi:10.1186/s40478-025-01931-2
de Vries, Luuk E; Jongejan, Aldo; Fortes, Jennifer Monteiro; Balesar, Rawien; Rozemuller, Annemieke J M; Moerland, Perry D; Huitinga, Inge; Swaab, Dick F; Verhaagen, Joost
阿尔茨海默症
线粒体
发表日期：2025
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Profiling a Neo-Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study of the KLH Challenge Model

在健康志愿者中分析新抗原驱动的免疫反应：一项KLH挑战模型的随机、双盲、安慰剂对照研究

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70007
Ronner, Micha N; Grievink, Hendrika W; Saghari, Mahdi; Osse, Michelle; van den Bosch, Thierry P P; Damman, Jeffrey; de Kam, Marieke L; Burggraaf, Jacobus; Klarenbeek, Naomi B; Jansen, Manon A A; Moerland, Matthijs
免疫/内分泌
发表日期：2025
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Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development

扩展IMQ模型：对人类TLR7反应进行深度表征，以用于早期药物开发

期刊:Inflammation
影响因子:5
doi:10.1007/s10753-024-02127-x
van den Noort, Juliette A; Assil, Salma; Ronner, Micha N; Osse, Michelle; Pot, Iris; Yavuz, Yalçin; Damman, Jeffrey; Lubberts, Erik; Rissmann, Robert; der Kolk, Tessa Niemeyer-van; Tomljanovic, Ingrid; Jansen, Manon A A; Moerland, Matthijs
Human
发表日期：2025
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Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

健康志愿者的新抗原免疫反应：来自多项钥孔血蓝蛋白挑战研究的重复免疫和反应协变量的启示

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1717333
Ronner, Micha N; De Kam, Marieke L; Van Reeuwijk, Silke; Burggraaf, Jacobus; Jansen, Manon A A; Moerland, Matthijs
免疫/内分泌
发表日期：2025
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Divergent gene signatures and neutrophil enrichment in lymph nodes of inflammatory arthritis patients

炎症性关节炎患者淋巴结中不同的基因特征和中性粒细胞富集

期刊:Arthritis Research & Therapy
影响因子:4.6
doi:10.1186/s13075-025-03557-0
O'Byrne, Aoife M; Bolt, Janne W; van Ansenwoude, Chaja M J; van der Heijde, Martijn; Semmelink, Johanna F; Jongejan, Aldo; Moerland, Perry D; Maas, Mario; van de Sande, Marleen G H; van Baarsen, Lisa G M
炎症
中性粒细胞
细胞生物学
炎症/感染
粒细胞
关节炎
发表日期：2025
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