日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

突破障碍：皮内注射脂多糖激发试验作为健康志愿者体内可控诱导血管渗漏的体内模型的特征分析

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70126
van Ruissen, Marella Cornelia Elizabeth; van Diemen, Menno; Botros, Liza; Tomljanovic, Ingrid; Achbo, Hind; Eleftheriou, Dimitra; Schenk, Paul Willem; Klarenbeek, Naomi Bertine; Gilroy, Derek William; Jansen, Manon Aleida Adriana; Moerland, Matthijs
发表日期：2026
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First-In-Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT-02 Freebase, a CNS-Penetrant NLRP3 Inhibitor

VENT-02 游离碱（一种可穿透血脑屏障的 NLRP3 抑制剂）的首次人体安全性、药代动力学和药效学研究

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.70578
Smidt, Lisanne C A; Moerland, Matthijs; Jansen, Manon A A; Kremer, Philip H C; Sille, Alexandra A J; Strugala, Pamela K; Klaassen, Erica S; Auger, Anick; Jananji, Silvana; Faidi, Rania; Pike, Kelly A; Warner, Loraine; Matta, Andre; Valencia, Xavier; Spiegelstein, Ofer
NLRP3
Human
神经科学
LRP3
血脑屏障
发表日期：2026
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POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study

POLB 001（一种 p38 MAPK 抑制剂）可降低健康志愿者体内注射 LPS 后引起的局部和全身炎症反应：一项随机、双盲、安慰剂对照研究

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1684307
de Bruin, Digna T; Jansen, Manon A A; Pereira, Diana R; van Schijndel, Lisa; Klaassen, Erica S; Otto, Marije E; Skillington, Jeremy; Maguire, Paula; Tremble, Liam; Bell, Alan; Maher, Laura; Mihara, Katsuhiro; Sumeray, Mark; Gilroy, Derek W; Klarenbeek, Naomi B; Moerland, Matthijs
炎症/感染
炎症
p38 MAPK
MAPK/ERK
发表日期：2025
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Profiling a Neo-Antigen-Driven Immune Response in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Study of the KLH Challenge Model

在健康志愿者中分析新抗原驱动的免疫反应：一项KLH挑战模型的随机、双盲、安慰剂对照研究

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70007
Ronner, Micha N; Grievink, Hendrika W; Saghari, Mahdi; Osse, Michelle; van den Bosch, Thierry P P; Damman, Jeffrey; de Kam, Marieke L; Burggraaf, Jacobus; Klarenbeek, Naomi B; Jansen, Manon A A; Moerland, Matthijs
免疫/内分泌
发表日期：2025
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Extending the IMQ Model: Deep Characterization of the Human TLR7 Response for Early Drug Development

扩展IMQ模型：对人类TLR7反应进行深度表征，以用于早期药物开发

期刊:Inflammation
影响因子:5
doi:10.1007/s10753-024-02127-x
van den Noort, Juliette A; Assil, Salma; Ronner, Micha N; Osse, Michelle; Pot, Iris; Yavuz, Yalçin; Damman, Jeffrey; Lubberts, Erik; Rissmann, Robert; der Kolk, Tessa Niemeyer-van; Tomljanovic, Ingrid; Jansen, Manon A A; Moerland, Matthijs
Human
发表日期：2025
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Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

健康志愿者的新抗原免疫反应：来自多项钥孔血蓝蛋白挑战研究的重复免疫和反应协变量的启示

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1717333
Ronner, Micha N; De Kam, Marieke L; Van Reeuwijk, Silke; Burggraaf, Jacobus; Jansen, Manon A A; Moerland, Matthijs
免疫/内分泌
发表日期：2025
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Translating in vitro gut microbiota models to human context: compositional correlations under dietary fiber intervention

将体外肠道菌群模型转化到人体环境中：膳食纤维干预下的组成相关性

期刊:Frontiers in Microbiology
影响因子:4.5
doi:10.3389/fmicb.2025.1708906
Hoevenaars, Femke P M; Scheithauer, Torsten P M; Eveleens Maarse, Boukje C; de Oliveira, Isabela M; Warnke, Ines; Sybesma, Wilbert; Moerland, Matthijs; van den Broek, Tim J; Schuren, Frank H J
微生物学
肠道菌群
发表日期：2025
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A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study.

益生元干预可改善健康女性的日常生活情绪，但对男性则无此效果：一项更大规模的双盲安慰剂对照交叉研究的探索性结果

期刊:Brain Behavior Immunity Health
影响因子:3.5
doi:10.1016/j.bbih.2024.100918
Hogenelst Koen, Krone Tanja, Eveleens Maarse Boukje, Warnke Ines, Snabel Jessica, van den Broek Tim J, Schuren Frank, Moerland Matthijs, Hoevenaars Femke P M
其它
发表日期：2025
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Microvascular effects of a mixed meal tolerance test: a model validation study

混合餐耐受试验对微血管的影响：模型验证研究

期刊:Clinical Physiology and Functional Imaging
影响因子:1.3
doi:10.1111/cpf.12904
van Kraaij, Sebastiaan J W; Eveleens Maarse, Boukje Charlotte; Hoevenaars, Femke P M; Warnke, Ines; de Kam, Marieke L; Moerland, Matthijs; Gal, Pim
发表日期：2025
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Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T-cell proliferation but residual T-cell activity during maintenance immunosuppressive treatment

肾移植稳定期患者的免疫反应：维持免疫抑制治疗期间T细胞增殖完全抑制，但仍存在残余T细胞活性

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.13860
In 't Veld, Aliede E; Eveleens Maarse, Boukje C; Juachon, Maria J; Meziyerh, Soufian; de Vries, Aiko P J; van Rijn, Aline L; Feltkamp, Mariet C W; Moes, Dirk Jan A R; Burggraaf, Jacobus; Moerland, Matthijs
细胞生物学
T细胞
T细胞
免疫/内分泌
发表日期：2024
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