日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microglial response to sleep deprivation depends on the hippocampal region and paradigm used in adult male mice.

成年雄性小鼠中,小胶质细胞对睡眠剥夺的反应取决于海马区域和所使用的范式。

Kox Janine, Picard Katherine, Šimončičová Eva, Vidal Virginie, Khakpour Mohammadparsa, Wilhelm Sophia, Burns Sophia, González Ibáñez Fernando, Ben-Azu Benneth, Havekes Robbert, Tremblay Marie-Ève

Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease

MEF2C在人类小胶质细胞中的转录和表观遗传靶点参与了与自闭症风险和年龄相关疾病相关的细胞功能。

Nguyen, Celina; Broersma, Emily H; Warden, Anna S; Mora, Cristina; Han, Claudia Z; Keulen, Zahara; Spann, Nathanael; Wang, Jing; Ramirez, Gabriela; Mak, Samantha; Trescott, Samantha; Khakpour, Mohammadparsa; Johnson, Avalon; Qureshi, Fatir; La Frano, Michael R; Mohajeri, Kiana; Talkowski, Michael E; Corradin, Olivia; Tremblay, Marie-Ève; Glass, Christopher K; Coufal, Nicole G

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion

与暗色小胶质细胞和毒性脂质分泌相关的神经退行性细胞应激反应

Anna Flury,Leen Aljayousi,Hye-Jin Park,Mohammadparsa Khakpour,Jack Mechler,Siaresh Aziz,Jackson D McGrath,Pragney Deme,Colby Sandberg,Fernando González Ibáñez,Olivia Braniff,Thi Ngo,Simira Smith,Matthew Velez,Denice Moran Ramirez,Dvir Avnon-Klein,John W Murray,Jia Liu,Martin Parent,Susana Mingote,Norman J Haughey,Sebastian Werneburg,Marie-Ève Tremblay,Pinar Ayata

Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus

在成年小鼠海马的正常生理条件下,性染色体和性激素以不同的方式塑造小胶质细胞的特性

Bianca Caroline Bobotis, Mohammadparsa Khakpour, Olivia Braniff, Elisa Gonçalves de Andrade, Makenna Gargus, Micah Allen, Micaël Carrier, Joanie Baillargeon, Manu Rangachari, Marie-Ève Tremblay2

Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase

临床使用的HIF脯氨酰羟化酶抑制剂Desidustat的衍生物是人γ-丁酰甜菜碱羟化酶的有效抑制剂

Corner, Thomas P; Tumber, Anthony; Salah, Eidarus; Jabbary, Mohammadparsa; Nakashima, Yu; Schnaubelt, Lara I; Basak, Shyam; Alshref, Faisal M; Brewitz, Lennart; Schofield, Christopher J

Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis

纤连蛋白-2是少突胶质细胞的一种细胞外基质抑制剂,与多发性硬化症相关。

Samira Ghorbani ,Cenxiao Li ,Brian M Lozinski ,Dorsa Moezzi ,Charlotte D'Mello ,Yifei Dong ,Frank Visser ,Hongmin Li ,Claudia Silva ,Mohammadparsa Khakpour ,Colin J Murray ,Marie-Ève Tremblay ,Mengzhou Xue ,V Wee Yong

Microglia degrade Alzheimer's amyloid-beta deposits extracellularly via digestive exophagy

小胶质细胞通过消化外吞噬作用将阿尔茨海默病淀粉样β蛋白沉积物降解到细胞外

Rudy G Jacquet, Fernando González Ibáñez, Katherine Picard, Lucy Funes, Mohammadparsa Khakpour, Gunnar K Gouras, Marie-Ève Tremblay, Frederick R Maxfield, Santiago Solé-Domènech

Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

暗色小胶质细胞在正常的出生后发育过程中大量存在,它们通过吞噬作用和胞吞作用重塑突触,并且依赖于TREM2。

Vecchiarelli, Haley A; Bisht, Kanchan; Sharma, Kaushik; Weiser Novak, Sammy; Traetta, Marianela E; Garcia-Segura, Monica Emili; St-Pierre, Marie-Kim; Savage, Julie C; Willis, Cory; Picard, Katherine; Bordeleau, Maude; Vernoux, Nathalie; Khakpour, Mohammadparsa; Garg, Rishika; Loewen, Sophia M; Murray, Colin J; Grinberg, Yelena Y; Faustino, Joel; Halvorson, Torin; Lau, Victor; Pluchino, Stefano; Vexler, Zinaida S; Carson, Monica J; Manor, Uri; Peruzzotti-Jametti, Luca; Tremblay, Marie-Ève

Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples

老年 APP-PS1 小鼠和人类死后脑样本的海马中星形胶质细胞表现出超微结构改变和异质性

Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, Martin Parent, Marie-Ève Tremblay

Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia

肠道-小胶质细胞-脑轴中新出现的表观遗传动力学:对精神分裂症患者加速脑衰老的实验和临床意义

Ben-Azu, Benneth; Del Re, Elisabetta C; VanderZwaag, Jared; Carrier, Micaël; Keshavan, Matcheri; Khakpour, Mohammadparsa; Tremblay, Marie-Ève