日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model

猪心室肌和人干细胞衍生心肌细胞模型中β-肌球蛋白R403Q突变导致收缩功能改变的分子机制

期刊:Journal of Molecular and Cellular Cardiology
影响因子:4.7
doi:10.1016/j.yjmcc.2025.10.008
Steczina, Sonette; Mohran, Saffie; Childers, Matthew C; McMillen, Timothy S; Naim, Ateeqa; Pilagov, Matvey; Dente, Marica; Kooiker, Kristina B; Mandrycky, Christian; Tawde, Khushi; Hesson, Jennifer; Zhao, Jing; Mathieu, Julie; Pioner, J Manuel; Geeves, Michael A; Ma, Weikang; Moussavi-Harami, Farid; Kad, Neil M; Regnier, Michael
细胞生物学
发育与干细胞
干细胞
发表日期：2025
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Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration

MYH7 G256E 突变导致不完全外显的肥厚型心肌病，引起心肌收缩力增强和线粒体呼吸增强。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2318413121
Lee, Soah; Vander Roest, Alison S; Blair, Cheavar A; Kao, Kerry; Bremner, Samantha B; Childers, Matthew C; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E; Roberts, Brock; Smith, Jacqueline E; Jahng, James W; Paik, David T; Wu, Joseph C; Gunawardane, Ruwanthi N; Ruppel, Kathleen M; Mack, David L; Pruitt, Beth L; Regnier, Michael; Wu, Sean M; Spudich, James A; Bernstein, Daniel
心肌病
MYH7
MYH
心血管
线粒体
发表日期：2024
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MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy

MYBPC3-c.772G>A 突变导致肥厚型心肌病患者诱导干细胞衍生心肌细胞模型中单倍体功能不全和肌球蛋白循环动力学改变。

期刊:Journal of Molecular and Cellular Cardiology
影响因子:4.7
doi:10.1016/j.yjmcc.2024.04.010
Steczina, Sonette; Mohran, Saffie; Bailey, Logan R J; McMillen, Timothy S; Kooiker, Kristina B; Wood, Neil B; Davis, Jennifer; Previs, Michael J; Olivotto, Iacopo; Pioner, Josè Manuel; Geeves, Michael A; Poggesi, Corrado; Regnier, Michael
心肌病
细胞生物学
心血管
干细胞
发育与干细胞
发表日期：2024
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The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca(2+)]

肌球蛋白调节轻链磷酸化的结构和功能效应会因肌节长度和[Ca(2+)]的增加而增强。

期刊:Journal of Physiology-London
影响因子:4.4
doi:10.1113/JP286802
Turner, Kyrah L; Vander Top, Blake J; Kooiker, Kristina B; Mohran, Saffie; Mandrycky, Christian; McMillen, Tim; Regnier, Michael; Irving, Thomas C; Ma, Weikang; Tanner, Bertrand C W
信号转导
磷酸化
发表日期：2024
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Beyond Conventional Treatments: Exploring CAR-T Cell Therapy for Cancer Stem Cell Eradication

超越传统疗法：探索CAR-T细胞疗法根除癌症干细胞

期刊:Stem Cell Reviews and Reports
影响因子:4.2
doi:10.1007/s12015-024-10786-4
Rabie, Lobna E; Mohran, Ahmed A; Gaber, Kholoud A; Ali, Nour M; Abd El Naby, Asmaa M; Ghoniem, Eman A; Abd Elmaksod, Basmala A; Abdallah, Ahmed N
肿瘤
T细胞
肿瘤免疫
细胞生物学
T细胞
干细胞
发育与干细胞
免疫/内分泌
发表日期：2024
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The biochemically defined super relaxed state of myosin-A paradox

生化定义的肌球蛋白超松弛状态-A悖论

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1016/j.jbc.2023.105565
Saffie Mohran, Kristina Kooiker, Max Mahoney-Schaefer, Christian Mandrycky, Kerry Kao, An-Yue Tu, Jeremy Freeman, Farid Moussavi-Harami, Michael Geeves, Michael Regnier
发表日期：2024
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Calcium has a direct effect on thick filament activation in porcine myocardium

钙对猪心肌粗丝活化有直接作用

期刊:Journal of General Physiology
影响因子:2.9
doi:10.1085/jgp.202413545
Mohran, Saffie; McMillen, Timothy S; Mandrycky, Christian; Tu, An-Yue; Kooiker, Kristina B; Qian, Wenjing; Neys, Stephanie; Osegueda, Brayan; Moussavi-Harami, Farid; Irving, Thomas C; Regnier, Michael; Ma, Weikang
发表日期：2024
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Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor.

一种新型的调节性轻链依赖性心肌肌球蛋白抑制剂的作用机制

期刊:Journal of General Physiology
影响因子:2.9
doi:10.1085/jgp.202313503
Kooiker Kristina, Gan Qing-Fen, Yu Ming, Sa Na, Mohran Saffie, Cheng Yuanhua, Flint Galina, Neys Stephanie, Gao Chengqian, Nissen Devin, McMillen Tim, Asencio Anthony, Ma Weikang, Irving Thomas C, Moussavi-Harami Farid, Regnier Michael
炎症/感染
心肌炎
发表日期：2024
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Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle

Danicamtiv 增加心肌肌球蛋白募集并改变横桥循环

期刊:Circulation Research
影响因子:16.2
doi:10.1161/CIRCRESAHA.123.322629
Kooiker, Kristina B; Mohran, Saffie; Turner, Kyrah L; Ma, Weikang; Martinson, Amy; Flint, Galina; Qi, Lin; Gao, Chengqian; Zheng, Yahan; McMillen, Timothy S; Mandrycky, Christian; Mahoney-Schaefer, Max; Freeman, Jeremy C; Costales Arenas, Elijah Gabriela; Tu, An-Yu; Irving, Thomas C; Geeves, Michael A; Tanner, Bertrand C W; Regnier, Michael; Davis, Jennifer; Moussavi-Harami, Farid
发表日期：2023
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Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

多尺度模型揭示肥厚型心肌病MYH7 G256E突变驱动心肌收缩力增强和线粒体呼吸增强

期刊:
影响因子:
doi:10.1101/2023.06.08.544276
Lee, Soah; Roest, Alison S Vander; Blair, Cheavar A; Kao, Kerry; Bremner, Samantha B; Childers, Matthew C; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie; Roberts, Brock; Smith, Jacqueline E; Jahng, James W; Paik, David T; Wu, Joseph C; Gunawardane, Ruwanthi N; Spudich, James A; Ruppel, Kathleen; Mack, David; Pruitt, Beth L; Regnier, Michael; Wu, Sean M; Bernstein, Daniel
心肌病
MYH7
MYH
心血管
线粒体
发表日期：2023
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