日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer

一种经Fc工程改造的糖基化抗体可促进免疫效应细胞的促炎激活并抑制乳腺癌的进展。

Chenoweth, Alicia M; Cheung, Anthony; Chauhan, Jitesh; Adams, Rebecca; Osborn, Gabriel; Stoker, Katie; Grandits, Melanie; Laddach, Roman; Trendell, Jennifer; Navarro-Llinas, Blanca; Suriawinata, Erin; Gross, Amanda; Clarke, Amanda; Brown, Lev; Cserny, Judit; Moise, Lenny; Jatiani, Shashi; McCraw, Alexandra; Esapa, Benjamina; Haider, Syed; Quist, Jelmar; Ilieva, Kristina M; Davies, Anna M; Romero-Clavijo, Pablo; Sénard, Thomas; Cheeseman, Jack; Gardner, Richard A; Spencer, Daniel I R; Tsoka, Sophia; Irshad, Sheeba; McDonnell, James M; Grigoriadis, Anita; Tutt, Andrew N J; Karagiannis, Sophia N

Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction

抗肿瘤IgE抗体MOv18诱导卵巢癌患者巨噬细胞发生过度炎症性极化,从而限制了免疫抑制性巨噬细胞与Treg细胞的相互作用。

Osborn, Gabriel; López-Abente, Jacobo; Adams, Rebecca; Laddach, Roman; Grandits, Melanie; Bax, Heather J; Chauhan, Jitesh; Pellizzari, Giulia; Nakamura, Mano; Stavraka, Chara; Chenoweth, Alicia; Palhares, Lais C G F; Evan, Theodore; Lim, Jessica Hui Cheah; Gross, Amanda; Moise, Lenny; Jatiani, Shashi; Figini, Mariangela; Bianchini, Rodolfo; Jensen-Jarolim, Erika; Ghosh, Sharmistha; Montes, Ana; Sayasneh, Ahmad; Kristeleit, Rebecca; Tsoka, Sophia; Spicer, James; Josephs, Debra H; Karagiannis, Sophia N

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques.

复制型RNA疫苗可保护食蟹猴免受克里米亚-刚果出血热的侵害

Hawman David W, Leventhal Shanna, Meade-White Kimberly, Graham William, Gaffney Karen, Khandhar Amit, Murray Justin, Prado-Smith Jessy, Shaia Carl, Saturday Greg, Buda Henry, Moise Lenny, Erasmus Jesse, Feldmann Heinz

With great power, comes great responsibility: the importance of broadly measuring Fc-mediated effector function early in the antibody development process

能力越大,责任越大:在抗体研发早期阶段广泛测量Fc介导的效应功能至关重要。

Crescioli, Silvia; Jatiani, Shashi; Moise, Lenny

A SARS-CoV-2 NSP7 homolog of a Treg epitope suppresses CD4+ and CD8+ T cell memory responses

SARS-CoV-2 NSP7 同源物与 Treg 表位相关,可抑制 CD4+ 和 CD8+ T 细胞记忆反应。

Miah, S M Shahjahan; Lelias, Sandra; Gutierrez, Andres H; McAllister, Mitchell; Boyle, Christine M; Moise, Lenny; De Groot, Anne S

From bench to bedside via bytes: Multi-omic immunoprofiling and integration using machine learning and network approaches

从实验室到临床:利用机器学习和网络方法进行多组学免疫分析和整合

Xiao, Hanxi; Rosen, Aaron; Chhibbar, Prabal; Moise, Lenny; Das, Jishnu

New Immunoinformatics Tools for Swine: Designing Epitope-Driven Vaccines, Predicting Vaccine Efficacy, and Making Vaccines on Demand

用于猪的新型免疫信息学工具:设计表位驱动疫苗、预测疫苗效力以及按需生产疫苗

Moise, Lenny; Gutiérrez, Andres H; Khan, Sundos; Tan, Swan; Ardito, Matt; Martin, William D; De Groot, Anne S

Immune-engineered H7N9 influenza hemagglutinin improves protection against viral influenza virus challenge

经免疫工程改造的H7N9流感血凝素可提高对病毒性流感病毒攻击的保护能力

Jang, Hyesun; Meyers, Lauren M; Boyle, Christine; De Groot, Anne S; Moise, Lenny; Ross, Ted M

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

2019 年新型冠状病毒 SARS-CoV-2 的免疫脆弱性情况

Zhu, James; Kim, Jiwoong; Xiao, Xue; Wang, Yunguan; Luo, Danni; Jiang, Shuang; Chen, Ran; Xu, Lin; Zhang, He; Moise, Lenny; Gutierrez, Andres H; De Groot, Anne S; Xiao, Guanghua; Schoggins, John W; Zhan, Xiaowei; Wang, Tao; Xie, Yang

Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models

多抗原疫苗联合OX40受体激活可延缓恶性间皮瘤生长并提高动物模型的生存率

Hoffmann, Peter R; Hoffmann, Fukun W; Premeaux, Thomas A; Fujita, Tsuyoshi; Soprana, Elisa; Panigada, Maddalena; Chew, Glen M; Richard, Guilhem; Hindocha, Pooja; Menor, Mark; Khadka, Vedbar S; Deng, Youping; Moise, Lenny; Ndhlovu, Lishomwa C; Siccardi, Antonio; Weinberg, Andrew D; De Groot, Anne S; Bertino, Pietro