日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibitor-induced dimerization mediates lufotrelvir resistance in mutants of SARS-CoV-2 3C-like protease

抑制剂诱导的二聚化介导SARS-CoV-2 3C样蛋白酶突变体对卢福替韦的耐药性

Wang, Guanyu; Venegas, Felipe; Rueda, Andres; Yañez, Osvaldo; Osorio, Manuel I; Qin, Sibei; Pérez-Donoso, José Manuel; Thibodeaux, Christopher J; Moitessier, Nicolas; Mittermaier, Anthony K

A sensitive and scalable fluorescence anisotropy single stranded RNA targeting approach for monitoring riboswitch conformational states

一种灵敏且可扩展的荧光各向异性单链 RNA 靶向方法,用于监测核糖开关构象状态

Maira Rivera, Omma S Ayon, Suzana Diaconescu-Grabari, Joshua Pottel, Nicolas Moitessier, Anthony Mittermaier, Maureen McKeague

A naturally occurring G11S mutation in the 3C-like protease from the SARS-CoV-2 virus dramatically weakens the dimer interface

SARS-CoV-2病毒3C样蛋白酶中天然存在的G11S突变会显著削弱二聚体界面。

Wang, Guanyu; Venegas, Felipe A; Rueda, Andres M; Weerasinghe, Nuwani W; Uggowitzer, Kevin A; Thibodeaux, Christopher J; Moitessier, Nicolas; Mittermaier, Anthony K

14 examples of how LLMs can transform materials science and chemistry: a reflection on a large language model hackathon

14 个 LLM 如何变革材料科学和化学的案例:对大型语言模型黑客马拉松的反思

Jablonka, Kevin Maik; Ai, Qianxiang; Al-Feghali, Alexander; Badhwar, Shruti; Bocarsly, Joshua D; Bran, Andres M; Bringuier, Stefan; Brinson, L Catherine; Choudhary, Kamal; Circi, Defne; Cox, Sam; de Jong, Wibe A; Evans, Matthew L; Gastellu, Nicolas; Genzling, Jerome; Gil, María Victoria; Gupta, Ankur K; Hong, Zhi; Imran, Alishba; Kruschwitz, Sabine; Labarre, Anne; Lála, Jakub; Liu, Tao; Ma, Steven; Majumdar, Sauradeep; Merz, Garrett W; Moitessier, Nicolas; Moubarak, Elias; Mouriño, Beatriz; Pelkie, Brenden; Pieler, Michael; Ramos, Mayk Caldas; Ranković, Bojana; Rodriques, Samuel G; Sanders, Jacob N; Schwaller, Philippe; Schwarting, Marcus; Shi, Jiale; Smit, Berend; Smith, Ben E; Van Herck, Joren; Völker, Christoph; Ward, Logan; Warren, Sean; Weiser, Benjamin; Zhang, Sylvester; Zhang, Xiaoqi; Zia, Ghezal Ahmad; Scourtas, Aristana; Schmidt, K J; Foster, Ian; White, Andrew D; Blaiszik, Ben

A cryptic third active site in cyanophycin synthetase creates primers for polymerization

蓝藻素合成酶中隐秘的第三个活性位点为聚合创造了引物

Itai Sharon, Sharon Pinus, Marcel Grogg, Nicolas Moitessier, Donald Hilvert, T Martin Schmeing

Augmented base pairing networks encode RNA-small molecule binding preferences

增强的碱基配对网络编码RNA-小分子结合偏好

Oliver, Carlos; Mallet, Vincent; Gendron, Roman Sarrazin; Reinharz, Vladimir; Hamilton, William L; Moitessier, Nicolas; Waldispühl, Jérôme

Enzyme Kinetics by Isothermal Titration Calorimetry: Allostery, Inhibition, and Dynamics

利用等温滴定量热法研究酶动力学:变构、抑制和动力学

Wang, Yun; Wang, Guanyu; Moitessier, Nicolas; Mittermaier, Anthony K

Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry

通过等温滴定量热法快速测量抑制剂结合动力学

Justin M Di Trani, Stephane De Cesco, Rebecca O'Leary, Jessica Plescia, Claudia Jorge do Nascimento, Nicolas Moitessier, Anthony K Mittermaier

Revised Mechanism for a Ruthenium-Catalyzed Coupling of Aldehyde and Terminal Alkyne

醛与末端炔烃钌催化偶联反应的修正机理

Tomberg, Anna; Kundu, Soumen; Zhou, Feng; Li, Chao-Jun; Moitessier, Nicolas

Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation

受限氮杂环 FTY720 类似物的磷酸化可增强抗白血病活性,而不会诱导 S1P 受体活化

A N McCracken, R J McMonigle, J Tessier, R Fransson, M S Perryman, B Chen, A Keebaugh, E Selwan, S A Barr, S M Kim, S G Roy, G Liu, D Fallegger, L Sernissi, C Brandt, N Moitessier, A J Snider, S Clare, M Müschen, A Huwiler, M T Kleinman, S Hanessian, A L Edinger