日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.

恶性疟原虫中持续存在血浆蛋白酶-哌喹悖论

Walsh Breanna, Summers Robert L, Rangel Gabriel W, Hagenah Laura M, Mok Sachel, Llinás Manuel, Fidock David A, Wirth Dyann F, Bopp Selina

Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost

恶性疟原虫非洲型PfCRT突变异构体虽然罕见,但会导致哌喹耐药性,且会造成严重的适应性损失。

Hagenah, Laura M; Yeo, Tomas; Schindler, Kyra A; Jeon, Jin H; Bloxham, Talia S; Small-Saunders, Jennifer L; Mok, Sachel; Fidock, David A

Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins

对青蒿素敏感性不同的非洲和亚洲恶性疟原虫分离株的配子体产生和传播适应性

Proellochs, Nicholas I; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N; Okitwi, Martin; Tumwebaze, Patrick K; Conrad, Melissa D; Clark, Taane G; Fidock, David A; Ménard, Didier; Mok, Sachel; Bousema, Teun

Effects of recombination on multi-drug resistance evolution in Plasmodium falciparum malaria

重组对恶性疟原虫疟疾多重耐药性进化的影响

Tran, Kien Trung; Nguyen, Tran Dang; Weissman, Daniel B; Li, Eric Zhewen; Mok, Sachel; Small-Saunders, Jennifer L; Bousema, Teun; Zupko, Robert J; Tran, Thu Nguyen-Anh; Boni, Maciej F

Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins

对青蒿素敏感性不同的非洲和亚洲恶性疟原虫分离株的配子体产生和传播适应性

Proellochs, Nicholas I; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N; Okitwi, Martin; Tumwebaze, Patrick K; Conrad, Melissa D; Clark, Taane G; Fidock, David A; Menard, Didier; Mok, Sachel; Bousema, Teun

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489 与哌喹之间的协同超敏反应可中和 PfCRT 介导的药物外排和恶性疟原虫耐药性。

Okombo, John; Ndiaye, Tolla; Qahash, Tarrick; Moura, Igor M R; Gil-Iturbe, Eva; Hagenah, Laura M; Bridgford, Jessica L; Bonatto, Vinicius; Ward, Kurt E; Yeo, Tomas; Narwal, Sunil K; Orta, Lily V; Anderson, Isla; Dhingra, Satish K; Pasaje, Charisse Flerida A; Park, Heekuk; Kim, Jonathan; Guido, Rafael V C; Angulo-Barturen, Iñigo; Niles, Jacquin C; Mancia, Filippo; Uhlemann, Anne-Catrin; Mok, Sachel; Quick, Matthias; Winzeler, Elizabeth A; Leroy, Didier; Llinás, Manuel; Thathy, Vandana; Fidock, David A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Determinants of piperaquine-resistant malaria in South America

南美洲哌喹耐药疟疾的决定因素

Mok, Sachel; Fidock, David A

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.

绘制恶性疟原虫多重耐药性的基因组图谱及其对寄生虫适应性的影响

Mok Sachel, Yeo Tomas, Hong Davin, Shears Melanie J, Ross Leila S, Ward Kurt E, Dhingra Satish K, Kanai Mariko, Bridgford Jessica L, Tripathi Abhai K, Mlambo Godfree, Burkhard Anna Y, Fairhurst Kate J, Gil-Iturbe Eva, Park Heekuk, Rozenberg Felix D, Kim Jonathan, Mancia Filippo, Quick Matthias, Uhlemann Anne-Catrin, Sinnis Photini, Fidock David A

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

哌喹耐药的PfCRT突变对恶性疟原虫无性血液期药物转运、血红蛋白分解代谢和寄生虫生理的影响各不相同。

Okombo, John; Mok, Sachel; Qahash, Tarrick; Yeo, Tomas; Bath, Jade; Orchard, Lindsey M; Owens, Edward; Koo, Imhoi; Albert, Istvan; Llinás, Manuel; Fidock, David A